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Nano optical and electrochemical sensors and biosensors for detection of narrow therapeutic index drugs

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Abstract

For the first time, a comprehensive review is presented on the quantitative determination of narrow therapeutic index drugs (NTIDs) by nano optical and electrochemical sensors and biosensors. NTIDs have a narrow index between their effective doses and those at which they produce adverse toxic effects. Therefore, accurate determination of these drugs is very important for clinicians to provide a clear judgment about drug therapy for patients. Routine analytical techniques have limitations such as being expensive, laborious, and time-consuming, and need a skilled user and therefore  the nano/(bio)sensing technology leads to high interest.

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Funding

Financial support of this study was provided by deputy of research and technology, Hamadan University of Medical Sciences.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

    Omid Heydari Shayesteh

  2. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Omid Heydari Shayesteh

  3. Nutrition Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Omid Heydari Shayesteh & Akram Ranjbar

  4. Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

    Reza Mahjub & Katayoun Derakhshandeh

  5. Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

    Akram Ranjbar & Mahdi Jamshidi

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  1. Omid Heydari Shayesteh
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  2. Reza Mahjub
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  3. Akram Ranjbar
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  4. Katayoun Derakhshandeh
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Correspondence to Omid Heydari Shayesteh.

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Shayesteh, O.H., Mahjub, R., Ranjbar, A. et al. Nano optical and electrochemical sensors and biosensors for detection of narrow therapeutic index drugs. Microchim Acta 188, 411 (2021). https://doi.org/10.1007/s00604-021-05003-9

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