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Non-drug-induced nephrotoxicity

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Abstract

Several drugs and other compounds can induce acute and/or chronic nephrotoxicity. The goal of this study was to review clinical features of nephrotoxicity induced by ‘atypical’ or ‘unconventional’ agents, such as environmental agents (metals, minerals, animals), food agents (mushrooms, aristolochic acid, medicinal traditional herbals, dietary supplements, melamine), drugs, and other products (ethylene glycol). Nephrotoxicity varies according to local background, dependent on different food and cultural customs, as well as to differences in local fauna and flora. The incidence of such a phenomenon is not well known. Many different pathophysiological pathways are involved, and the spectrum of renal lesions is rather wide. ‘Epidemic nephrotoxicity’ may occur, as recently illustrated by the melamine epidemics in Chinese infants receiving powdered milk formulas; a rapid reaction to unusual increased frequency of acute kidney injury and nephrolithiasis in young children has led to a rapid analysis from international experts, with subsequent recommendations for diagnosis and care. Nephrotoxicity should be considered when there is any unexplained renal impairment, especially in children.

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Authors and Affiliations

  1. Centre de Référence des Maladies Rénales Rares, Service de Néphrologie et Rhumatologie Pédiatriques, Hôpital Femme Mère Enfant, Boulevard Pinel, 69677, Bron, France

    Justine Bacchetta & Pierre Cochat

  2. Université de Lyon, Lyon, France

    Justine Bacchetta, Laurence Dubourg, Laurent Juillard & Pierre Cochat

  3. Service d’Exploration Fonctionnelle Rénale et Métabolique, Hôpital Edouard Herriot, Lyon, France

    Laurence Dubourg

  4. INSERM 820, Lyon, France

    Laurence Dubourg & Pierre Cochat

  5. Département de Néphrologie, Hôpital Edouard Herriot, Lyon, France

    Laurent Juillard

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  1. Justine Bacchetta
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  2. Laurence Dubourg
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  3. Laurent Juillard
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  4. Pierre Cochat
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Correspondence to Pierre Cochat.

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Bacchetta, J., Dubourg, L., Juillard, L. et al. Non-drug-induced nephrotoxicity. Pediatr Nephrol 24, 2291–2300 (2009). https://doi.org/10.1007/s00467-009-1180-3

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