Modeling of chromosome aberration response functions induced by particle beams with different LET
This study is based on our already published experimental data (Kowalska et al. in Radiat Environ Biophys 58:99–108, 2019) and is devoted to modeling of chromosome aberrations in human lymphocytes induced by 22.1 MeV/u 11B ions, 199 MeV/u 12C ions, 150 MeV and spread-out Bragg peak (SOBP) proton beams as well as by 60Co γ rays. The curvature of the dose–effect curves determined by the linear-quadratic model was considered in the frame of a simple analytical approach taking into account increase in the irradiation dose due to overlapping interaction regions of ion tracks. The model enabled to estimate effective interaction radius which could be compared with the physical expectations. The results were also compared to the Amorphous Track Structure Model of Katz which allows to get some additional information about the ion track structure. The analysis showed that the curvature of the experimental dose–effect curves mainly results from highly efficient repair processes of the DNA damage.
KeywordsChromosome aberrations Local energy deposition Ion track structure Linear-quadratic model
We thank the staff of the Medical Centre of JINR and Flerov Laboratory of Nuclear Reactions, JINR, for supporting the accelerator studies, as well as Golubev A.A. and Markov N.V. (ITEP, Moscow, Russia) for providing the opportunity of carbon irradiation at the ITEP-TWAC accelerator and Dr. T. Friedrich (GSI, Darmstadt, Germany) for the evaluation of spatial dose distributions presented in Fig. 1.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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