Skip to main content
Log in

Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation

  • Correspondence
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Centenaro LA, Jaeger Mda C, Ilha J, de Souza MA, Kalil-Gaspar PI, Cunha NB, Marcuzzo S, Achaval M (2011) Olfactory and respiratory lamina propria transplantation after spinal cord transection in rats: effects on functional recovery and axonal regeneration. Brain Res 1426:54–72. doi:10.1016/j.brainres.2011.09.054

    Article  CAS  PubMed  Google Scholar 

  2. Dlouhy BJ, Awe O, Rao RC, Kirby PA, Hitchon PW (2014) Autograft-derived spinal cord mass following olfactory mucosal cell transplantation in a spinal cord injury patient: case report. J Neurosurg Spine 21:618–622. doi:10.3171/2014.5.SPINE13992

    Article  PubMed  Google Scholar 

  3. Goni VG, Chhabra R, Gupta A, Marwaha N, Dhillon MS, Pebam S, Gopinathan NR, Bangalore Kantharajanna S (2014) Safety profile, feasibility and early clinical outcome of cotransplantation of olfactory mucosa and bone marrow stem cells in chronic spinal cord injury patients. Asian Spine J 8:484–490. doi:10.4184/asj.2014.8.4.484

    Article  PubMed  PubMed Central  Google Scholar 

  4. Iwatsuki K, Yoshimine T, Kishima H, Aoki M, Yoshimura K, Ishihara M, Ohnishi Y, Lima C (2008) Transplantation of olfactory mucosa following spinal cord injury promotes recovery in rats. Neuroreport 19:1249–1252. doi:10.1097/WNR.0b013e328305b70b

    Article  PubMed  Google Scholar 

  5. Lima C, Escada P, Pratas-Vital J, Branco C, Arcangeli CA, Lazzeri G, Maia CA, Capucho C, Hasse-Ferreira A, Peduzzi JD (2010) Olfactory mucosal autografts and rehabilitation for chronic traumatic spinal cord injury. Neurorehabilit Neural Repair 24:10–22. doi:10.1177/1545968309347685

    Article  Google Scholar 

  6. Mackay-Sim A, Feron F, Cochrane J, Bassingthwaighte L, Bayliss C, Davies W, Fronek P, Gray C, Kerr G, Licina P et al (2008) Autologous olfactory ensheathing cell transplantation in human paraplegia: a 3-year clinical trial. Brain: J Neurol 131:2376–2386. doi:10.1093/brain/awn173

    Article  CAS  Google Scholar 

  7. Mackay-Sim A, St John JA (2011) Olfactory ensheathing cells from the nose: clinical application in human spinal cord injuries. Exp Neurol 229:174–180. doi:10.1016/j.expneurol.2010.08.025

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by grants from National Institutes of Health/National Institute on Deafness and Other Communication Disorders DC011990 (JCM) and DC009606 (JRM), National Institute of Neurological Disorders and Stroke R25NS089450 (KSC), and the A. Alfred Taubman Medical Research Institute (PGP).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kevin S. Chen.

Additional information

K. S. Chen and J. C. McIntyre contributed equally to the manuscript.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 9719 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, K.S., McIntyre, J.C., Lieberman, A.P. et al. Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation. Acta Neuropathol 131, 639–640 (2016). https://doi.org/10.1007/s00401-016-1543-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00401-016-1543-3

Keywords

Navigation