Skip to main content
SpringerLink
Log in

Preparation of nanoparticle colloids of methoxy poly(ethylene glycol)-b-poly(D,L-lactide): effects of surfactant and organic solvent

  • Short Communication
  • Published:
Colloid and Polymer Science Aims and scope Submit manuscript

Abstract

Nanoparticle colloids of methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (MPEG-b-PDLL) diblock copolymer were prepared by a modified spontaneous emulsification solvent diffusion method using acetone/ethanol as the mixture organic solvents. The MPEG-b-PDLL was synthesized by ring-opening polymerization of D,L-lactide using stannous octoate and MPEG with molecular weight of 5,000 g/mol as the initiating system. The MPEG-b-PDLL obtained was an amorphous polymer with molecular weight of 73,600 g/mol. Influences of acetone/ethanol (v/v) ratios and Tween 80 surfactant concentrations on characteristics of the colloidal nanoparticles were investigated and discussed. Light-scattering analysis showed that average diameters of the surfactant-free colloidal nanoparticles were in the range of 86–124 nm. The nanoparticle sizes decreased as the ethanol ratio increased. The Tween 80 did not show the significant effect on the nanoparticle sizes. Scanning electron micrographs of dried nanoparticles that demonstrated the aggregation of most particles suggested they were the soft nanoparticles. However, the dried nanoparticle morphology can be observed from scanning electron microscopy as having a spherical shape and smooth surfaces.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Lucke A, Tebmar J, Schnell E, Schmeer G, Gopferich A (2000) Biomaterials 21:2361

    Article  CAS  Google Scholar 

  2. Sun J, Hong Z, Yang L, Tang Z, Chen X, Jing X (2004) Polymer 45:5969

    Article  CAS  Google Scholar 

  3. Stefani M, Coudane J, Vert M (2006) Polym Degrad Stab 91:2554

    Article  CAS  Google Scholar 

  4. Kim SY, Shin IG, Lee YM (1998) J Control Release 56:197

    Article  CAS  Google Scholar 

  5. Kim SY, Lee YM, Kang JS (2005) J Biomed Mater Res 74A:581

    Article  CAS  Google Scholar 

  6. Pierri E, Avgoustakis K (2005) J Biomed Mater Res 75A:639

    Article  CAS  Google Scholar 

  7. Faria TJ, Campos AM, Senna EL (2005) Macromol Symp 229:228

    Article  CAS  Google Scholar 

  8. Riley T, Heald CR, Stolnik S, Garnett MC, Illum L, Davis SS (2003) Langmuir 19:8428

    Article  CAS  Google Scholar 

  9. Stolnik S, Illum L, Davis SS (1995) Adv Drug Deliv Rev 16:195

    Article  CAS  Google Scholar 

  10. Stolnik S, Heald CR, Neal J, Garnett MC, Davis SS, Illum L, Purkiss SC, Barlow RJ, Gellert PR (2001) J Drug Target 9:361

    Article  CAS  Google Scholar 

  11. Gorner T, Gref R, Michenot D, Sommer F, Tran MN, Dellacherie E (1999) J Control Release 57:259

    Article  CAS  Google Scholar 

  12. Belbella A, Vauthier C, Fessi H, Devissaguet J-P, Puisieux F (1996) Int J Pharm 129:95

    Article  CAS  Google Scholar 

  13. Hu Y, Jiang X, Ding Y, Zhang L, Yang C, Zhang J, Chen J, Yang Y (2003) Biomaterials 24:2395

    Article  CAS  Google Scholar 

  14. Allemann E, Leroux JC, Gurnay R, Doelker E (1993) Pharm Res 10:1732

    Article  CAS  Google Scholar 

  15. Dai Z, Piao L, Zhang X, Deng M, Chen X, Jing X (2004) Colloid Polym Sci 282:343

    Article  CAS  Google Scholar 

  16. Murakami H, Kobayashi M, Takeuchi H, Kawashima Y (1999) Int J Pharm 187:143

    Article  CAS  Google Scholar 

  17. Niwa T, Takeuchi H, Hino T, Kunou N, Kawashima Y (1993) J Control Release 25:89

    Article  CAS  Google Scholar 

  18. Magenheim B, Benita S (1991) STP Pharm Sci 1:221

    CAS  Google Scholar 

  19. Quintanar-Guerrero D, Fessi H, Allemann E, Doelker E (1996) Int J Pharm 143:133

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge the Faculty of Science, Mahasarakham University, and the Thailand Research Fund (TRF) for financial support (DBG4880008). The authors would like to thank Mr. Teerasak Kerdchan from the Faculty of Pharmacy, Mahasarakham University, Mahasarakham, Thailand, for light-scattering particle size analysis.

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Mahasarakham University, Mahasarakham, 44150, Thailand

    Yodthong Baimark, Mangkorn Srisa-ard & Jirasak Threeprom

  2. Central Instrumentation Unit, Faculty of Science, Mahasarakham University, Mahasarakham, 44150, Thailand

    Nual-Anong Narkkong

Authors
  1. Yodthong Baimark
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mangkorn Srisa-ard
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jirasak Threeprom
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nual-Anong Narkkong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yodthong Baimark.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baimark, Y., Srisa-ard, M., Threeprom, J. et al. Preparation of nanoparticle colloids of methoxy poly(ethylene glycol)-b-poly(D,L-lactide): effects of surfactant and organic solvent. Colloid Polym Sci 285, 1521–1525 (2007). https://doi.org/10.1007/s00396-007-1731-8

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00396-007-1731-8

Keywords

Search

Navigation