Colloid and Polymer Science

, Volume 285, Issue 13, pp 1521–1525

Preparation of nanoparticle colloids of methoxy poly(ethylene glycol)-b-poly(D,L-lactide): effects of surfactant and organic solvent

  • Yodthong Baimark
  • Mangkorn Srisa-ard
  • Jirasak Threeprom
  • Nual-Anong Narkkong
Short Communication


Nanoparticle colloids of methoxy poly(ethylene glycol)-b-poly(D,L-lactide) (MPEG-b-PDLL) diblock copolymer were prepared by a modified spontaneous emulsification solvent diffusion method using acetone/ethanol as the mixture organic solvents. The MPEG-b-PDLL was synthesized by ring-opening polymerization of D,L-lactide using stannous octoate and MPEG with molecular weight of 5,000 g/mol as the initiating system. The MPEG-b-PDLL obtained was an amorphous polymer with molecular weight of 73,600 g/mol. Influences of acetone/ethanol (v/v) ratios and Tween 80 surfactant concentrations on characteristics of the colloidal nanoparticles were investigated and discussed. Light-scattering analysis showed that average diameters of the surfactant-free colloidal nanoparticles were in the range of 86–124 nm. The nanoparticle sizes decreased as the ethanol ratio increased. The Tween 80 did not show the significant effect on the nanoparticle sizes. Scanning electron micrographs of dried nanoparticles that demonstrated the aggregation of most particles suggested they were the soft nanoparticles. However, the dried nanoparticle morphology can be observed from scanning electron microscopy as having a spherical shape and smooth surfaces.


MPEG-b-poly(D,L-lactide) Spontaneous emulsification solvent diffusion method Nanoparticle colloids Soft particles 


  1. 1.
    Lucke A, Tebmar J, Schnell E, Schmeer G, Gopferich A (2000) Biomaterials 21:2361CrossRefGoogle Scholar
  2. 2.
    Sun J, Hong Z, Yang L, Tang Z, Chen X, Jing X (2004) Polymer 45:5969CrossRefGoogle Scholar
  3. 3.
    Stefani M, Coudane J, Vert M (2006) Polym Degrad Stab 91:2554CrossRefGoogle Scholar
  4. 4.
    Kim SY, Shin IG, Lee YM (1998) J Control Release 56:197CrossRefGoogle Scholar
  5. 5.
    Kim SY, Lee YM, Kang JS (2005) J Biomed Mater Res 74A:581CrossRefGoogle Scholar
  6. 6.
    Pierri E, Avgoustakis K (2005) J Biomed Mater Res 75A:639CrossRefGoogle Scholar
  7. 7.
    Faria TJ, Campos AM, Senna EL (2005) Macromol Symp 229:228CrossRefGoogle Scholar
  8. 8.
    Riley T, Heald CR, Stolnik S, Garnett MC, Illum L, Davis SS (2003) Langmuir 19:8428CrossRefGoogle Scholar
  9. 9.
    Stolnik S, Illum L, Davis SS (1995) Adv Drug Deliv Rev 16:195CrossRefGoogle Scholar
  10. 10.
    Stolnik S, Heald CR, Neal J, Garnett MC, Davis SS, Illum L, Purkiss SC, Barlow RJ, Gellert PR (2001) J Drug Target 9:361CrossRefGoogle Scholar
  11. 11.
    Gorner T, Gref R, Michenot D, Sommer F, Tran MN, Dellacherie E (1999) J Control Release 57:259CrossRefGoogle Scholar
  12. 12.
    Belbella A, Vauthier C, Fessi H, Devissaguet J-P, Puisieux F (1996) Int J Pharm 129:95CrossRefGoogle Scholar
  13. 13.
    Hu Y, Jiang X, Ding Y, Zhang L, Yang C, Zhang J, Chen J, Yang Y (2003) Biomaterials 24:2395CrossRefGoogle Scholar
  14. 14.
    Allemann E, Leroux JC, Gurnay R, Doelker E (1993) Pharm Res 10:1732CrossRefGoogle Scholar
  15. 15.
    Dai Z, Piao L, Zhang X, Deng M, Chen X, Jing X (2004) Colloid Polym Sci 282:343CrossRefGoogle Scholar
  16. 16.
    Murakami H, Kobayashi M, Takeuchi H, Kawashima Y (1999) Int J Pharm 187:143CrossRefGoogle Scholar
  17. 17.
    Niwa T, Takeuchi H, Hino T, Kunou N, Kawashima Y (1993) J Control Release 25:89CrossRefGoogle Scholar
  18. 18.
    Magenheim B, Benita S (1991) STP Pharm Sci 1:221Google Scholar
  19. 19.
    Quintanar-Guerrero D, Fessi H, Allemann E, Doelker E (1996) Int J Pharm 143:133CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Yodthong Baimark
    • 1
  • Mangkorn Srisa-ard
    • 1
  • Jirasak Threeprom
    • 1
  • Nual-Anong Narkkong
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceMahasarakham UniversityMahasarakhamThailand
  2. 2.Central Instrumentation Unit, Faculty of ScienceMahasarakham UniversityMahasarakhamThailand

Personalised recommendations