Abstract.
Although knowledge of basic genetics in the field of sclerosing bone dysplasias is progressing, the radiologist still plays a pivotal role in the diagnosis of this relatively poorly understood group of disorders. Based on a target site approach, these anomalies are classified into three groups. Within each group, further differentiation can be made by distinctive clinical findings and by mode of inheritance: (a) dysplasias of endochondral bone formation: osteopetrosis (Albers-Schönberg disease), pycnodysostosis, enostosis, osteopoikilosis, osteopathia striata (Voorhoeve disease); (b) dysplasias of intramembranous bone formation: progressive diaphyseal dysplasia (Camurati-Engelmann disease) and variants, hyperostosis corticalis generalisata (Van Buchem disease) and variants; and (c) mixed sclerosing dysplasias: melorheostosis (Leri disease) and overlap syndromes.
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Received: 11 January 2000; Revised: 5 April 2000; Accepted: 6 April 2000
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Vanhoenacker, F., De Beuckeleer, L., Van Hul, W. et al. Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol 10, 1423–1433 (2000). https://doi.org/10.1007/s003300000495
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DOI: https://doi.org/10.1007/s003300000495