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Cancer Chemotherapy and Pharmacology

, Volume 71, Issue 5, pp 1115–1130 | Cite as

A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis

  • Samira Sadat Abolmaali
  • Ali Mohammad Tamaddon
  • Rassoul Dinarvand
Review Article

Abstract

Purpose

Methotrexate (MTX) is one of the most widely studied and effective therapeutics agents available to treat many solid tumors, hematologic malignancies, and autoimmune diseases such as rheumatoid arthritis; however, the poor pharmacokinetic and narrow safety margin of the drug limits the therapeutic outcomes of conventional drug delivery systems. For an improved delivery of MTX, several pathophysiological features such as angiogenesis, enhanced permeability and retention effects, acidosis, and expression of specific antigens and receptors can be used either as targets or as tools for drug delivery.

Methods

There are many novel delivery systems developed to improve the pitfalls of MTX therapy ranged from polymeric conjugates such as human serum albumin, liposomes, microspheres, solid lipid nanoparticles, polymeric nanoparticles, dendrimers, polymeric micelles, in situ forming hydrogels, carrier erythrocyte, and nanotechnology-based vehicles such as carbon nanotubes, magnetic nanoparticles, and gold nanoparticles. Some are further modified with targeting ligands for active targeting purposes.

Results

Such delivery systems provide prolonged plasma profile, enhanced and specific activity in vitro and in vivo in animal models. Nevertheless, more complementary studies are needed before they can be applied in human.

Conclusion

This review deals with the challenges of conventional systems and achievements of each pharmaceutical class of novel drug delivery vehicle.

Keywords

Methotrexate Cancer Rheumatoid arthritis Drug delivery Nanoparticle Drug conjugate Human serum albumin Liposome Microsphere Dendrimer 

Notes

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Samira Sadat Abolmaali
    • 1
  • Ali Mohammad Tamaddon
    • 1
  • Rassoul Dinarvand
    • 2
  1. 1.Pharmaceutical Nanotechnology and Biomaterials Research Center, Faculty of PharmacyShiraz University of Medical SciencesShirazIran
  2. 2.Nanotechnology Research Centre, Faculty of PharmacyTehran University of Medical SciencesTehranIran

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