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World Journal of Surgery

, Volume 39, Issue 1, pp 216–222 | Cite as

Major Post-Operative Complications Predict Long-Term Survival After Esophagectomy in Patients with Adenocarcinoma of the Esophagus

  • Guillaume Luc
  • Marlène Durand
  • Laurence Chiche
  • Denis Collet
Original Scientific Report

Abstract

Background

Esophagectomy provides the best opportunity for a long-term cure despite its high post-operative morbidity. We reviewed our institutional records to evaluate the impact of major post-operative complications on the long-term survival of patients following esophagectomy after neoadjuvant treatment for locally advanced adenocarcinoma.

Methods

We identified 241 patients who underwent esophagectomy as a curative procedure at our tertiary referral center. All consecutive patients with locally advanced adenocarcinoma of the esophagus who underwent neoadjuvant treatment followed by esophagectomy were analyzed. Complications were graded according to the Clavien scale. Patients were compared according to the complication grade (grades 0–1–2 vs. grades 3–4). Overall survival and disease-free survival were calculated using the Kaplan–Meier method, and survival curves were compared using log-rank tests. Factors predictive of survival were determined using multivariate analysis.

Results

A total of 116 patients underwent esophagectomy after neoadjuvant treatment for locally advanced adenocarcinoma of the esophagus. Fifty-four patients (46.5 %) developed post-operative complications. The post-operative mortality rate was 4.3 % (five patients). Patients with grade 3–4 complications had decreased overall survival and disease-free survival rates (p = 0.006 and 0.045). Grade 3–4 complications and positive nodes were found to be contributing factors to survival (p = 0.027 and 0.005).

Conclusions

Our single-institution study found that major morbidity had a negative impact on long-term survival in patients who underwent esophagectomy after neoadjuvant treatment for locally advanced adenocarcinoma.

Keywords

Overall Survival Docetaxel Positive Node Esophageal Carcinoma Lower Esophagus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

No grant support was received.

Conflicts of interest

No conflicts of interest exist.

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Copyright information

© Société Internationale de Chirurgie 2014

Authors and Affiliations

  • Guillaume Luc
    • 1
  • Marlène Durand
    • 2
  • Laurence Chiche
    • 1
  • Denis Collet
    • 1
  1. 1.Department of Digestive SurgeryUniversity Hospital of BordeauxBordeauxFrance
  2. 2.CIC-IT, Hospital Xavier ArnozanUniversity Hospital of BordeauxBordeauxFrance

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