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Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms

Abstract

Biomaterials play a fundamental role in disease management and the improvement of health care. In recent years, there has been a significant growth in the diversity, function, and number of biomaterials used worldwide. Yet, attachment of pathogenic microorganisms onto biomaterial surfaces remains a significant challenge that substantially undermines their clinical applicability, limiting the advancement of these systems. The emergence and escalating pervasiveness of antibiotic-resistant bacterial strains makes the management of biomaterial-associated nosocomial infections increasingly difficult. The conventional post-operative treatment of implant-caused infections using systemic antibiotics is often marginally effective, further accelerating the extent of antimicrobial resistance. Methods by which the initial stages of bacterial attachment and biofilm formation can be restricted or prevented are therefore sought. The surface modification of biomaterials has the potential to alleviate pathogenic biofouling, therefore preventing the need for conventional antibiotics to be applied.

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Acknowledgements

This study was supported in part by Australian Research Council (ARC) and Advanced Manufacturing CRC.K. B. is a recipient of an Australian Postgraduate Award (APA) and an Australian Institute of Nuclear Science and Engineering Postgraduate Research Award (AINSE PGRA).

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Correspondence to Russell J. Crawford or Elena P. Ivanova.

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Bazaka, K., Jacob, M.V., Crawford, R.J. et al. Efficient surface modification of biomaterial to prevent biofilm formation and the attachment of microorganisms. Appl Microbiol Biotechnol 95, 299–311 (2012). https://doi.org/10.1007/s00253-012-4144-7

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Keywords

  • Biomaterials
  • Surface treatment
  • Biofilm
  • Bacterial attachment