Abstract
The frequency of newborns with congenital heart disease (CHD) is approximately 1% in the general population; however, the recurrence rate of CHD in mothers with CHD differs in ethnicity and reports. We therefore aimed to determine the prevalence of CHD among neonates born to mothers with CHD in our institute in Japan. We reviewed the medical charts of 803 neonates delivered by 529 women with CHD at the National Cerebral and Cardiovascular Center from 1982 to 2016. They included isolated ventricular septal defect (VSD,31.4%), isolated atrial septal defect (ASD, 23.3%), tetralogy of Fallot (TOF,10.6%). We defined CHD in neonates as being diagnosed within 1 month of birth. We estimated that the average rate of the CHD recurrence was 3.1%. The recurrence ratios in each maternal CHD were 8.6%, 7.1%, 6.2%, 4.8%, 3.6%, and 1.5% for PS, CoA, TOF, atrioventricular septal defect, VSD, and ASD, respectively. The rate of CHD in offsprings whose mothers have CHD was 3 times greater than that of mothers with healthy hearts. Almost half of neonates with CHD had the same phenotype as their mother in our series. Especially, PS and CoA were closely related to the type of maternal CHD.
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References
Nora JJ, Nora AH (1998) Update on counseling the family with a first-degree relative with a congenital heart defect. Am J Med Genet 29:137–142
Nakazawa M, Seguchi M (1986) Birth rates and CHD incidence in live born babies from Japan Welfare Facilities survey in 1986. Jpn Pediatr 90:2578–2587 (in Japanese)
Reid GJ, Siu SC, McCrindle BW, Irvine MJ, Webb GD (2008) Sexual behavior and reproductive concerns among adolescents and young adultswith congenital heart disease. Int J Cardiol 125:332–338
Gill HK, Splitt M, Sharland GK, Simpson JM (2003) Patterns of recurrence of congenital heart disease: an analysis of 6640 consecutive pregnancies evaluated by detailed fetal echocardiography. J Am Coll Cardiol 42:923–929
Siu SC, Sermer M, Colman JM, Alvarez AN, Mercier LA, Morton BC, Kells CM, Bergin ML, Kiess MC, Marcotte F, Taylor DA, Gordon EP, Spears JC, Tam JW, Amankwah KS, Smallhorn JF, Farine D, Sorensen S (2001) Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation 104:515–521
Burn J, Brennan P, Little J, Holloway S, Coffey R, Somerville J, Dennis NR, Allan L, Arnold R, Deanfield JE, Godman M, Houston A, Keeton B, Oakley C, Scott O, Silove E, Wilkinson J, Pembrey M, Hunter AS (1998) Recurrence risks in offspring of adults with major heart defects: results from first cohort of British collaborative study. Lancet 351:311–316
Fesslova V, Brankovic J, Lalatta F, Villa L, Meli V, Piazza L, Ricci C (2011) Recurrence of congenital heart disease in cases with familial risk screened prenatally by echocardiography. J Pregnancy https://doi.org/10.1155/2011/368067
Peyvandi S, Ingall E, Woyciechowski S, Garbarini J, Mitchell LE, Goldmuntz E (2014) Risk of congenital heart disease in relatives of probands with conotruncal cardiac defects: an evaluation of 1620 families. Am J Med Genet A 164:1490–1495
Matsuoka R, Mori K, Ando M (2007) Japanese epidemiological study of congenital heart disease-1990 to 1999, 2654 families report. Jpn Soc Pediatr Cardiol Card Surg 19:606–621 (in Japanese)
Nora JJ (1994) From generational studies to a multilevel genetic-environmental interaction. J Am Coll Cardiol 23:1468–1471
Brodwall K, Greve G, Leirgul E, Tell GS, Vollset SE, Øyen (2017) Recurrence of congenital heart defects among siblings: a nationwide study. Am J Med Genet A 173:1575–1585
Calcagni G, Digilio MC, Sarkozy A, Dallapiccola B, Marino B (2007) Familial recurrence of congenital heart disease: an overview and review of the literature. Eur J Pediatr 166:111–116
Whittemore R, Wells JA, Castellsague X (1994) A second-generation study of 427 probands with congenital heart defects and their 837 children. J Am Coll Cardiol 23:1459–1467
Drenthen W, Pieper PG, van der Tuuk K, Roos-Hesselink JW, Voors AA, Mostert B, Mulder BJ, Moons P, Ebels T, van Veldhuisen DJ, Zahara Investigators (2005) Cardiac complications relating to pregnancy and recurrence of disease in the offspring of women with atrioventricular septal defects. Eur Heart J 26:2581–2587
Meijer JM, Pieper PG, Drenthen W, Voors AA, Roos-Hesselink JW, van Dijk AP, Mulder BJ, Ebels T, van Veldhuisen DJ (2005) Pregnancy, fertility, and recurrence risk in corrected tetralogy of Fallot. Heart 91:801–805
Richards AA, Garg V (2010) Genetics of congenital heart disease. Curr Cardiol Rev 6:91–97
Digilio MC, Marino B, Giannotti A, Toscano A, Dallapiccola B (1997) Recurrence risk figures for isolated tetralogy of Fallot after screening for 22q11 microdeletion. J Med Genet 34:188–190
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Yokouchi-Konishi, T., Yoshimatsu, J., Sawada, M. et al. Recurrent Congenital Heart Diseases Among Neonates Born to Mothers with Congenital Heart Diseases. Pediatr Cardiol 40, 865–870 (2019). https://doi.org/10.1007/s00246-019-02083-6
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DOI: https://doi.org/10.1007/s00246-019-02083-6