Platelet-rich plasma injection is effective and safe for the treatment of alopecia
- 980 Downloads
Mesotherapy has become a new method for the treatment of different types of alopecia. However, there is a paucity of data in the literature about its efficacy and side effects. In this retrospective study, safety, efficacy, and feasibility of platelet-rich plasma (PRP) injections were assessed.
Between October 2009 and October 2010, 42 patients (8 women and 34 men) with hair loss or androgenic alopecia were included in this study. Before each session, the hair pull test was performed three times. A total volume of 8–12 cc was injected by using 32 or 30.5 G needles. The treatment was repeated five times over a period of 2 months. Outcome measures were assessed after 3 months by clinical examination, macroscopic photos, pull clinical test, and the patient’s overall satisfaction.
Before treatment, 90.5 % of our patients had a positive pull test with a mean number of eight hairs. After the third session, the pull test was negative in all patients with an average number of three hairs. Global pictures showed a significant improvement in hair volume and quality, which was confirmed by a high overall patient satisfaction. The results were even more obvious in patients who suffered from alopecia for less than 2 years. Poorer results were found in patients with marked alopecia type VI–VII according Norwood classification in men.
PRP injections are simple and efficient, have minimal morbidity with a low cost-to-benefit ratio and can be regarded a valuable alternative for the treatment of alopecia.
Level of Evidence: Level IV, therapeutic study.
KeywordsPlatelets Hair loss Alopecia Receptors Growth factor
The authors would like to thank the Regenlab for providing the materials for this study.
Conflict of Interest
- 1.Powell BC, Rogers GE (1997) The role of keratin proteins and their genes in the growth, structure and properties of hair. In: Jollès P, Zahn, H., Höcker, H. (eds) Formation and structure of human hair. Birkhäuser Verlag, Basel, p 59–148Google Scholar
- 6.Kadry R, Hamadah I, Al-Issa A, Field L, Alrabiah F (2008) Multifocal scalp abscess with subcutaneous fat necrosis and scarring alopecia as a complication of scalp mesotherapy. J D Dermatol: JDD 7(1):72–73Google Scholar
- 14.Gardner MJ, Demetrakopoulos D, Klepchick PR, Mooar PA (2007) The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty. An analysis of the haemoglobin, narcotic requirement and range of motion. Int Orthop 31(3):309–313. doi: 10.1007/s00264-006-0174-z CrossRefPubMedGoogle Scholar
- 15.Glover JL, Weingarten MS, Buchbinder DS, Poucher RL, Deitrick GA 3rd, Fylling CP (1997) A 4-year outcome-based retrospective study of wound healing and limb salvage in patients with chronic wounds. Adv Wound Care: J Prev Healing 10(1):33–38Google Scholar
- 18.Katsuoka K, Schell H, Wessel B, Hornstein OP (1987) Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro. Arch Dermatol Res 279(4):247–250CrossRefPubMedGoogle Scholar