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Osteoporosis International

, Volume 29, Issue 12, pp 2597–2610 | Cite as

Bone management in hematologic stem cell transplant recipients

  • D. L. KendlerEmail author
  • J. J. Body
  • M. L. Brandi
  • R. Broady
  • J. Cannata-Andia
  • M. J. Cannata-Ortiz
  • A. El Maghraoui
  • G. Guglielmi
  • P. Hadji
  • D. D. Pierroz
  • T. J. de Villiers
  • R. Rizzoli
  • P. R. Ebeling
  • for the International Osteoporosis Foundation Committee of Scientific Advisors Working Group on Cancer and Bone Disease
Review

Abstract

Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) is the treatment of choice for patients with some malignant and non-malignant hematological diseases. Advances in transplantation techniques and supportive care measures have substantially increased the number of long-term HSCT survivors. This has led to an increasing patient population suffering from the late effects of HSCT, of which, bone loss and its consequent fragility fractures lead to substantial morbidity. Altered bone health, with consequent fragility fractures, and chronic graft-versus-host disease (GVHD) are factors affecting long-term quality of life after HSCT. Hypogonadism, HSCT preparative regimens, nutritional factors, and glucocorticoids all contribute to accelerated bone loss and increased fracture risk. Management strategies should include bone mineral density examination, evaluation of clinical risk factors, and general dietary and physical activity measures. Evidence has accumulated permitting recommendations for more attentiveness to evaluation and monitoring of bone health, with appropriate application of osteoporosis pharmacotherapies to patients at increased risk of bone loss and fracture.

Keywords

Bone loss Bone marrow Bone mineral density Fracture Hematopoietic stem cell Transplantation 

Notes

Compliance with ethical standards

Conflicts of interest

P Hadji received honoraria, travel grants, and scientific research grants from Amgen, Eli Lilly, MSD, Novartis, Pfizer, Procter & Gamble, and Roche. D Kendler received honoraria, speakers bureau, and/or research grants from Amgen, Eli Lilly, MSD, Pfizer, Astrazenica, and Astellas. T de Villiers has acted as a consultant or speaker for the following companies: Abbott, Amgen, Aspen, MSD, Pfizer. R Rizzoli received fees for consultancy or lectures from Danone, EffRx, Nestlé, ObsEva, and Radius Health. PR Ebeling received research grants, honoraria, and/or speakers’ fees from Amgen, Eli Lilly, Novartis, and Gilead. J Cannata-Andia received honoraria and scientific research grants from Amgen, Shire, and VIFOR/Fresenius. JJ Body, ML Brandi, MJ Cannata-Ortiz, A El Magrahoui, G Guglielmi, and DD Pierroz have no conflict of interest to declare.

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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2018

Authors and Affiliations

  • D. L. Kendler
    • 1
    Email author
  • J. J. Body
    • 2
  • M. L. Brandi
    • 3
  • R. Broady
    • 4
  • J. Cannata-Andia
    • 5
  • M. J. Cannata-Ortiz
    • 6
  • A. El Maghraoui
    • 7
  • G. Guglielmi
    • 8
  • P. Hadji
    • 9
  • D. D. Pierroz
    • 10
  • T. J. de Villiers
    • 11
    • 12
  • R. Rizzoli
    • 13
  • P. R. Ebeling
    • 14
  • for the International Osteoporosis Foundation Committee of Scientific Advisors Working Group on Cancer and Bone Disease
  1. 1.Department of Medicine, Division of EndocrinologyUniversity of British ColumbiaVancouverCanada
  2. 2.CHU BrugmannUniversité Libre de BruxellesBrusselsBelgium
  3. 3.Mineral and Bone Metabolic Unit, Department of Surgery and Translational MedicineUniversity of FlorenceFlorenceItaly
  4. 4.Department of Medicine, Division of HematologyUniversity of British ColumbiaVancouverCanada
  5. 5.Servicio de Metabolismo Óseo y Mineral, Hospital Universitario Central de AsturiasUniversidad de OviedoOviedoSpain
  6. 6.Haematology Department, IIS PrincesaHospital de la PrincesaMadridSpain
  7. 7.Rheumatology Department, Military Hospital Mohammed VMohammed V-Souissi UniversityRabatMorocco
  8. 8.Department of RadiologyUniversity of FoggiaFoggiaItaly
  9. 9.Department of Bone Oncology, Endocrinology and Reproductive MedicineNord West HospitalFrankfurtGermany
  10. 10.International Osteoporosis Foundation (IOF)NyonSwitzerland
  11. 11.Department of Gynaecology, Faculty of Health SciencesStellenbosch UniversityStellenboschSouth Africa
  12. 12.Mediclinic PanoramaCape TownSouth Africa
  13. 13.Division of Bone Diseases, Faculty of MedicineGeneva University HospitalGenevaSwitzerland
  14. 14.Department of Medicine, School of Clinical SciencesMonash UniversityClaytonAustralia

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