Osteoporosis International

, Volume 16, Issue 10, pp 1203–1209 | Cite as

Consumption of a high calcium mineral water lowers biochemical indices of bone remodeling in postmenopausal women with low calcium intake

  • Pierre J. MeunierEmail author
  • Cecile Jenvrin
  • Françoise Munoz
  • Viviane de la Gueronnière
  • Patrick Garnero
  • Michèle Menz
Original Article


Many postmenopausal women have a calcium intake far below the recommended amount and, in addition to attempting to improve their diet, need a calcium supplement. The aim of the study was to assess the effects of the consumption of a high calcium mineral water (HCaMW) on biochemical indices of bone remodeling in postmenopausal women with low Ca intake. A 6-month randomized double-blind placebo-controlled trial was designed to assess the effects of a daily consumption of 1 liter of a HCaMW (596 mg Ca/l) on serum parathyroid hormone (PTH) and biochemical markers of bone remodeling in postmenopausal women with a dietary Ca intake lower than 700 mg/day. The placebo group drank 1 liter of a mineral water with a low calcium content (10 mg/l). One hundred eighty healthy women were recruited (mean age: 70.1±4.0 years); 152 completed the 6-month trial. The changes from baseline of biochemical indices after 6 months consisted of a significant 14.1% decrease of serum PTH, osteocalcin (–8.6%), bone alkaline phosphatase (–11.5%), serum (–16.3%) and urine (–13.0%) type-1 collagen C-telopeptide in the HCaMW group compared to the placebo group, where all biochemical indices increased after 6 months. The additive effect of a small vitamin D supplement (400 iu/day) was also evaluated. In women receiving vitamin D in addition to HCaMW, the decrease in bone indices was not found to be greater than in women drinking only the HCaMW. A daily supplement of 596 mg of Ca through the consumption of 1 l of HCaMW was able to lower serum PTH and the indices of bone turnover in postmenopausal women with a low Ca intake. This could contribute to the repair of calcium deficiency and to the reduction of age-related bone loss in this population.


Biochemical markers of bone remodeling High calcium mineral water Low calcium intake Parathyroid hormone Postmenopausal women 


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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2005

Authors and Affiliations

  • Pierre J. Meunier
    • 1
    Email author
  • Cecile Jenvrin
    • 1
  • Françoise Munoz
    • 2
  • Viviane de la Gueronnière
    • 3
  • Patrick Garnero
    • 4
  • Michèle Menz
    • 5
  1. 1.Faculty of Medicine RTHLaennec Inserm Unit 403Lyon Cedex 08France
  2. 2.INSERM Unit 403LyonFrance
  3. 3.Centre Evian pour l’EauParisFrance
  4. 4.SYNARCLyonFrance
  5. 5.Centre Régional de Prévention des Institutions de RetraiteLyonFrance

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