Skip to main content
Log in

Do calcium supplements increase serum and urine calcium levels in post-menopausal women?

  • Published:
The journal of nutrition, health & aging

Abstract

Objectives

The frequent prescription of calcium supplements with vitamin D by health practitioners is a topic of concern globally. The present study was designed to find out whether the calcium supplements with vitamin D really affect serum and urinary calcium levels in post-menopausal women.

Design, Settings & Participants

The age-matched comparative study was performed among postmenopausal women who were already on and those who were not on calcium supplements with vitamin D for a period of time in relation to the estimation of the serum calcium and the urine calcium levels. Sixty healthy postmenopausal women were enrolled, with thirty among them forming the study group (SG) — who were on calcium supplements with vitamin D for a period of a month, three months, and up to twelve months — were studied and compared the results obtained with the age-matched control group (CG) of thirty post-menopausal women who were not on calcium supplements.

Measurements

The serum and the urinary calcium levels were estimated by using appropriate biochemical methods and the data were analysed using relevant statistical methods.

Results

The serum calcium levels did not vary significantly in SG in spite of consuming calcium supplements over a period of time, whereas the urinary calcium levels increased progressively (p value < 0.005) in those who have taken calcium supplements for a year compared to those who have taken for a month.

Conclusion

Thus, the calcium supplements were of little significance on the serum calcium levels, but have a significant effect on the urinary calcium levels in post-menopausal women.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Nordin BEC. Calcium and osteoporosis. Nutrition 1997;13: 664–686.

    Article  Google Scholar 

  2. Eugene, Paula B. The Parathyroid glands and vitamin D. In: Boron WF, Boulpaep E (eds). Medical Physiology, 2nd edn. W B Saunders Publishing, Philadelphia, 2003;pp 1094–1103.

    Google Scholar 

  3. Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. Academic Press, Washington DC, 2010.

    Google Scholar 

  4. National Institutes of Health. Optimal calcium intake: NIH Consensus Statement. 1994;12: 1–31.

    Google Scholar 

  5. Dawson-Hudges B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 1990;323: 878–883.

    Article  Google Scholar 

  6. Prince RL, Devine A, Dick I et al. The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women. J Bone Min Res 1995;10: 1068–1075.

    Article  CAS  Google Scholar 

  7. Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ. Long-term effects of calcium supplementation on bone loss and fractures in postmenopausal women — a randomized controlled trial. Am J Med 1995;98: 331–335.

    Article  CAS  PubMed  Google Scholar 

  8. McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL. Role of calcium in modulating age-related increases in parathyroid function and bone resorption. J Clin Endocrin Metab 1996;81:1699–1703.

    CAS  Google Scholar 

  9. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD et al. Effect of calcium supplements on the risk of myocardial infarction and cardiovascular events: meta-analysis. Brit Med J 2010;341: c3691 doi:10.1136/bmj.c3691.

    Article  Google Scholar 

  10. Reid IR, Mason B, Horne A, Ames R, Reid HE, Bava U et al. Randomized controlled trial of calcium in healthy older women. Am J Med 2006;119: 777–785.

    Article  CAS  PubMed  Google Scholar 

  11. Bolland MJ, Barber PA, Doughty RN, Mason B, Horne A, Ames R et al. Vascular events in healthy older women receiving calcium supplementation: randomized controlled trial. Brit Med J 2008;336: 262–266. doi: 10.1136/bmj.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Cleland JGF, Klaus W, Sue S. Calcium supplements in people with osteoporosis (2010) Brit Med J 2010;341: c3856. doi: 10.1136/bmj.c3856.

    Article  Google Scholar 

  13. Moyer VA. Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann Int Med 2013;158: 691–696. doi:10.7326/0003-4819-158-9-201305070-00603.

    PubMed  Google Scholar 

  14. Heaney RP. Calcium. In: Bilezikian JP, Raisz GA, Rodan GA (eds). Principles of ai]Bone Biology. Academic Press, New York, 1996;pp 1007–1018

    Google Scholar 

  15. Yoshida M, Fukuwatari T, Sakai J, Tsuji T, Shibanda K. Correlation between mineral intake and urinary excretion in free-living Japanese young women. Food Nutr Sci 2012;3: 123–128 doi:10.4236/fns.2012.31018].

    Article  CAS  Google Scholar 

  16. Heinrich T, Heidt H, Hafner V, Schmidt-Gayk H, Jenetzky E, Walter-Sack I et al. Calcium load during the administration of calcium carbonate or sevelamer in individuals with normal renal function. Neph Dial Transpl 2008;23, 2861–2867. doi: 10.1093/ndt/gfn151.

    Article  CAS  Google Scholar 

  17. Smith HG Jr, Baucer PJ. Light-induced permeability changes in sonicated bovine disks: arsenazo III and flow system measurements. Biochem 1979;18: 5067–5073.

    Article  CAS  Google Scholar 

  18. Budesinky B. Analyt Chem. Chelñates 1969;18: 5067–5073.

    Google Scholar 

  19. Cadwell PC. Calcium chelation buffers. In: Cuthbert AW (ed). Calcium and Cellular Function, Mackmillan Publishing Co Inc, London, 1970;pp 10–16.

    Google Scholar 

  20. Dawson-Hughes B, Harris SS, Palermo NJ, Castaneda-Sceppa C, Rasmussen HM, Dallal GE. Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women. J Clin Endocrin Metab 2009;94: 96–102.

    Article  CAS  Google Scholar 

  21. Goldman’s Cecil Medicine. Elsevier, Philadelphia, 2007.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. K. Kulkarni.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Samozai, M.N., Kulkarni, A.K. Do calcium supplements increase serum and urine calcium levels in post-menopausal women?. J Nutr Health Aging 19, 537–541 (2015). https://doi.org/10.1007/s12603-014-0532-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12603-014-0532-2

Key words

Navigation