Cellular and Molecular Life Sciences

, Volume 74, Issue 22, pp 4059–4075 | Cite as

Molecular mechanisms underlying Th1-like Treg generation and function

  • Alexandra Kitz
  • Margarita Dominguez-VillarEmail author


Since their ‘re-discovery’ more than two decades ago, FOXP3+ regulatory T cells (Tregs) have been an important subject of investigation in the biomedical field and our understanding of the mechanisms that drive their phenotype and function in health and disease has advanced tremendously. During the past few years it has become clear that Tregs are not a terminally differentiated population but show some degree of plasticity, and can, under specific environmental conditions, acquire the phenotype of effector T cells. In particular, recent works have highlighted the acquisition of a Th1-like phenotype by Tregs in several pathological environments. In this review we give an update on the concept of Treg plasticity and the advances in defining the molecular mechanisms that underlie the generation of Th1-like Tregs during an immune response and in different disease settings.


Foxp3 Plasticity Th1-Tregs AKT Therapy 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Departments of Neurology and ImmunobiologyYale School of MedicineNew HavenUSA
  2. 2.Department of Neurology, Human and Translational Immunology ProgramYale School of MedicineNew HavenUSA

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