Summary
The exact resectability of the pancreas without producing diabetes was investigated in dogs, with consideration of pancreatic regeneration.
Within the first week after major pancreatectomy, acinar cell division occurred, followed by hypertrophy; these changes resulted in an increase in weight of the remnant pancreas. The regeneration rate correlated well with the resection rate, glucose tolerance, and the insulin secretion of the remnant pancreas.
Immediately after resection of more than 92% of the pancreas, severe diabetes developed, and the regeneration rate was 29.9 ± 6.03% three to six weeks after surgery.
Twelve weeks after resection of 74–92% of the pancreas, so-called Sandmeyer's diabetes had developed. The regeneration rate was 45.3±4.22% in the non-diabetic group, but in the diabetic group it proved to be only 15.4±2.39%.
When less than 74% of the pancreas was resected, diabetes did not occur throughout the postoperative observation periods of 3–18 weeks, and the regeneration rate was 5.5±6.62%. These results suggested that 74% of the pancreas may be removed without producing diabetes.
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References
Child III, C.G., Fry, W.J. and Frey, C.F., Ninety-five percent distal pancreateatectomy for chronic pancreatitis, Ann. Surg., 1965; 162: 543–549.
Child III, C.G., Fry, W.J. and Frey, C.F., A reappraisal of removal of ninety-five percent of the distal portion of the pancreas, Surg. Gynecol. Obstet., 1969; 129: 49–56.
Jordan Jr, G.L., Complications of pancreatic and splenic surgery. In: C.P. Artz and J.D. Hardy (Eds.), Management of Surgical Complications, W.B. Saunders, Philadelphia, 1975; 560–562.
Mizumoto, R., Kawarada, Y., Goshima, H., et al., Carbohydrate metabolism and endocrine function in the pancreas remnant after major pancreatic resection, Am. J. Surg., 1982; 143: 237–243.
Allen, F.M. Experimental studies on diabetes, I. Production of diabetes in the dog. Gross anatomic relation of the pancreas and diabetes, J. Exp. Med., 1920; 30: 363–409.
Condorelli, A., Mancuso, M. and Ricceri, R., Experimental study of the regenerative eapacity of the pancreas after partial resection of the gland, Policlinico Sez. Chir., 1963; 70: 163–180.
Weibel, E.R., Practical stereological method for morphometric cytology, J Cell Biol., 1966; 30: 23–37.
O'Sullivan, J.B., Snyder, P.J., Sporter, A.C., et al., Intravenous glucose tolerance test and its modification by pregnancy, J. Clin. Endocrinol., 1970; 31: 33–37.
Olefsky, J.F., Farguhas, J.W. and Reaven, G.H., Do the oral and intravenous glucose tolerance tests provide similar diagnostic information in patients with chemical diabetes mellitus? Diabetes, 1973; 22: 202–209.
Sandmeyer, W., Über die Folgen der partiellen Pankreas-extirpation beim Hund, Z. Biol., 1895; 31: 12–85.
Pearson, K.W., Scott, D. and Torrance, B., Effects of partial surgical pancreatectomy in rats, I. Pancreatic regeneration, Gastroenterology, 1977; 72: 469–473.
Barrowman, J.A., The trophic action of gastrointestinal hormones, Digestion, 1975; 12: 92–104.
Johnson, L.R., Effects of gastrointestinal hormones on pancreatic growth, Cancer, 1981; 47: 1640–1645.
Couture, Y., Dunnigan, J. and Morisset, J., Stimulation of pancreatic amylase secretion and protein synthesis by insulin, Scand. J. Gastroenterol., 1972; 7: 257–263.
Fujita, T., Insulo-acinar portal system in the horse pancreas, Arch. Histol. Jpn., 1973; 35: 161–171.
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Mizumoto, R., Yano, T., Sekoguchi, T. et al. Resectability of the pancreas without producing diabetes, with special reference to pancreatic regeneration. Int J Pancreatol 1, 185–193 (1986). https://doi.org/10.1007/BF02795244
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DOI: https://doi.org/10.1007/BF02795244