Microbial Ecology

, Volume 12, Issue 1, pp 43–52

The ecology of antibiotic production

  • S. T. Williams
  • J. C. Vickers

Abstract

Over the last 40 years, there has been a steady supply of novel, useful antibiotics produced by microbes isolated from soil and other natural environments. The increased efficiency of screening procedures in the last decade has played a major part in maintaining this supply. However, the selection and sampling of natural environments are still essentially random processes. The main reasons for this are an almost total lack of knowledge of the significance of antibiotics in nature, deficiencies in the taxonomy of antibiotic-producing microbes and its application, and lack of information about the distribution and ecology of known or potential antibiotic producers. The origins of these problems are discussed and some possible solutions are suggested.

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References

  1. 1.
    Anke T, Hecht HJ, Schramm G, Steglich W (1979) Antibiotics from basidiomycetes. IX. Oudemansin, an antifungal antibiotic fromOudemansiella mucida (Schrader ex Fr.) Hoehnel (Agaricales). J Antibiot 32:1112–1117PubMedGoogle Scholar
  2. 2.
    Anek T, Kupke J, Schramm G, Steglich W (1980) Scorodonin, a new antibacterial and antifungal metabolite fromMarasmius scorodonius (Fr.). Fr J Antibiot 33:463–467Google Scholar
  3. 3.
    Baker KF (1980) Microbial antagonism—the potential for biological control. In: Ellwood DC, Hedger JH, Latham MJ, Lynch JM, Slater JH (eds) Contemporary microbial ecology, Academic Press, London and New York, pp 327–347Google Scholar
  4. 4.
    Berdy J (1980) Recent advances in and prospects of antibiotic research. Process Biochem 15:28–36Google Scholar
  5. 5.
    Brian PW (1957) The ecological significance of antibiotic production. In: Williams REC, Spicer CC (eds) (1957) Microbial ecology, Cambridge University Press, Cambridge, pp 168–188Google Scholar
  6. 6.
    Cassidy PJ (1982) Novel naturally occurringβ-lactam antibiotics—a review. Dev Indust Microbiol 22:181–209Google Scholar
  7. 7.
    Chet I, Baker R (1980) Induction of suppressiveness toRhizoctonia solani in soil. Phytopathology 70:994–998Google Scholar
  8. 8.
    Demain AL (1981) Applied microbiology: a personal view. In: Norris JR, Richmond MH (eds) Essays in applied microbiology, John Wiley, New York and Chichester, pp 1/1–1/31Google Scholar
  9. 9.
    Gottlieb D (1976) The production and role of antibiotics in soil. J Antibiot 29:987–1000PubMedGoogle Scholar
  10. 10.
    Gray TRG, Williams ST (1971) Microbial productivity in soil. In: Hughes DE, Rose AH (eds) Microbes and biological productivity, Cambridge University Press, Cambridge, pp 255–286Google Scholar
  11. 11.
    Hopwood DA (1981) Genetic studies of antibiotics and other secondary metabolites. In: Glover SW, Hopwood DA (eds) Genetics as a tool in microbiology, Cambridge University Press, Cambridge, pp 187–218Google Scholar
  12. 12.
    Horan AC, Brodsky BC (1982) A novel antibiotic-producingActinomadura, Actinomadura kijaniata sp.nov. Int J Syst Bacteriol 32:195–200Google Scholar
  13. 13.
    Hotta K, Okami Y, Umezawa H (1980) An actinomycete isolated from a marine environment. II. Possible involvement of plasmid in istamycin production. J Antibiot 33:1510–1514PubMedGoogle Scholar
  14. 14.
    Howell CR, Stipanovic RD (1979) Control ofRhizoctonia solani in cotton seedlings withPseudonomas fluorescens and with an antibiotic produced by the bacterium. Phytopathology 69:480–482Google Scholar
  15. 15.
    Hsu SC, Lockwood JL (1975) Powdered chitin as a selective medium for enumeration of actinomycetes in water and soil. Appl Microbiol 29:422–426PubMedGoogle Scholar
  16. 16.
    Imada A, Kitano K, Kintaka K, Muroi M, Asai M (1981) Sulfazecin and isosulfazecin, novelβ-lactam antibiotics of bacterial origin. Nature 289:590–591PubMedGoogle Scholar
  17. 17.
    Iwasaki A, Itoh H, Mori T (1981)Streptomyces annanensis sp. nov. Int J Syst Bacteriol 31:280–284Google Scholar
  18. 18.
    Jones KL (1949) Fresh isolates of actinomycetes in which the presence of sporogenous aerial mycelia is a fluctuating characteristic. J Bacteriol 57:141–145Google Scholar
  19. 19.
    Katz E, Demain AL (1977) The peptide antibiotics ofBacillus: chemistry, biogenesis and possible functions. Bacteriol Rev 41:449–474PubMedGoogle Scholar
  20. 20.
    Küster E, Williams ST (1964) Selection of media for isolation of streptomycetes. Nature:202, 928–929PubMedGoogle Scholar
  21. 21.
    Martin JE, Demain AL (1980) Control of antibiotic synthesis. Microbial Rev 44:230–251Google Scholar
  22. 22.
    Ouf MF, Mahmoud SAZ, Abdel-Nasser M (1981) Effect of inoculation with antagonistic microorganisms on severity ofFusarium wilt on tomato and water melon. Zentralbl Bakteriol Parasitenkd Infektionskr Hyg II 136:341–343Google Scholar
  23. 23.
    Papavizas GC, Lumsden RD (1980) Biological control of soil-bome fungal propagules. Ann Rev Phytopathol 18:389–413Google Scholar
  24. 24.
    Rothrock CS, Gottlieb D (1981) Importance of antibiotic production in antagonism of selectedStreptomyces species to two soil-borne plant pathogens. J Antibiot 34:830–835PubMedGoogle Scholar
  25. 25.
    Satei S, Muto N, Hayashi M, Fujii T, Otani M (1980) Mycinamicins, new macrolide antibiotics. I. Taxonomy, production, isolation, characterization and properties. J Antibiot 33:364–376PubMedGoogle Scholar
  26. 26.
    Scher FM, Baker R (1980) Mechanisms of biological control in aFusarium-suppressive soil. Phytopathology 70:412–417Google Scholar
  27. 27.
    Shomura T, Kojima M, Yoshida J, Ito M, Amano S, Totsugawa K, Niwa T, Inoyue S, Ito T, Niida T (1980) Studies on a new amino glycoside antibiotic dactimicin. 1. Producing organism and fermentation. J Antibiot 33:924–930PubMedGoogle Scholar
  28. 28.
    Sing PJ, Mehrotra RS (1980) Biological control ofRhizoctonia bataticola on grain by coating seed withBacillus andStreptomyces species, and their influence on plant growth. Pl Soil 56:475–483Google Scholar
  29. 29.
    Smiley RW (1978) Antagonists ofGaeumannomyces graminis from the rhizosphere of wheat in soils fertilised with ammonium—or nitrate—nitrogen. Soil Biol Biochem 10:169–174Google Scholar
  30. 30.
    Smiley RW (1978) Colonization of wheat roots byGaeumannomyces graminis inhibited by specific soils, micro-organisms and ammonium-nitrogen. Soil Biol Biochem 10:175–179Google Scholar
  31. 31.
    Sneath PHA (1980) BASIC program for the most diagnostic properties of groups from an identification matrix of percent positive characters. Computers and Geosciences 6:21–26Google Scholar
  32. 32.
    Soulides DA (1964) Antibiotics in soils. VI. Determination of microquantities of antibiotics in soil. Soil Sci 97:286–289Google Scholar
  33. 33.
    Soulides DA (1965) Antibiotics in soils. VII. Production of streptomycin and tetracyclines in soil. Soil Sci 100:200–206Google Scholar
  34. 34.
    Soulides DA, Pinck LA, Allison FE (1961) Antibiotics in soils. III. Further studies on release of antibiotics from clays. Soil Sci 92:90–93Google Scholar
  35. 35.
    Sykes RB, Cimarusti CM, Bonner DP, Bush K, Floyd DM, Georgopapadakou NH, Koster WH, Liu WC, Parker WL, Principe PA, Rathnum ML, Slusarchyk WA, Trejo WH, Wells JS (1981) Monocyclicβ-lactam antibiotics produced by bacteria. Nature 291:489–491PubMedGoogle Scholar
  36. 36.
    Torikata A, Enokita R, Okazaki T, Nakajima M, Iwado S, Haneishi T, Arai M (1983) Mycoplanecins, novel antimycobacterial antibiotics fromActinoplanes awajinensis subsp.mycoplanecinus subsp. nov. I. Taxonomy of producing organism and fermentation. J Antibiot 36:957–960PubMedGoogle Scholar
  37. 37.
    Trejo WH (1970) An evaluation of some concepts and criteria used in the speciation of streptomycetes. Trans New York Acad Sci 32:989–997Google Scholar
  38. 38.
    Vickers JC, Williams ST, Ross GW (1985) A taxonomic approach to selective isolation of streptomycetes from soil. In: Ortiz-Ortiz L, Bojalil LF, Yakoleff (eds) Biological, biochemical, and biomedical aspects of actinomycetes. Academic Press, Orlando, pp 553–561Google Scholar
  39. 39.
    Waksman SA (1956) The role of antibiotics in natural processes. Giorn Microbiol 2:1–14Google Scholar
  40. 40.
    Weller DM (1983) Colonization of wheat roots by a fluorescent pseudomonad suppressive to take-all. Phytopathology 73:1548–1553Google Scholar
  41. 41.
    Weller DM, Cook RJ (1983) Suppression of take-all of wheat by seed treatments with fluorescent pseudomonads. Phytopathology 73:463–469Google Scholar
  42. 42.
    Williams ST (1982) Are antibiotics produced in soil? Pedobiologia 23:427–435Google Scholar
  43. 43.
    Williams ST (1985) Oligotrophy in soil—fact or fiction? In: Fletcher M, Floodgate GD (eds) Bacteria in their natural environments. Academic Press, London, pp 81–110Google Scholar
  44. 44.
    Williams ST, Khan MR (1974) Antibiotics—a soil microbiologist's viewpoint. Post Hig I Med Dows 28:395–408Google Scholar
  45. 45.
    Williams ST, Wellington EMH (1982) Principles and problems of selective isolation of microbes. In: Bu'lock JD, Nisbet LJ, Winstanley DJ (eds) Bioactive microbial products: search and discovery. Academic Press, London, pp 9–26Google Scholar
  46. 46.
    Williams ST, Goodfellow M, Alderson G, Wellington EMH, Sneath PHA, Sackin MJ (1983) Numerical classification ofStreptomyces and related genera. J Gen Microbiol 129:1743–1813PubMedGoogle Scholar
  47. 47.
    Williams ST, Goodfellow M, Wellington EMH, Vickers JC, Alderson G, Sneath PHA, Sackin MJ, Mortimer AM (1983) A probability matrix for identification of some streptomycetes. J Gen Microbiol 129:1815–1830PubMedGoogle Scholar
  48. 48.
    Williams ST, Goodfellow M, Vickers JC (1984) New microbes from old habitats? In: Kelly DP, Carr NG (eds) The microbe 1984. Part II. Prokaryotes and eukaryotes, Cambridge University Press, Cambridge, pp 219–256Google Scholar
  49. 49.
    Witkamp M, Starkey RL (1973) Some factors affecting the determination of antibiotics in soil. Soil Sci 115:376–379Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • S. T. Williams
    • 1
  • J. C. Vickers
    • 1
  1. 1.Department of BotanyUniversity of LiverpoolLiverpoolUK

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