Summary
The pharmacokinetics of isosorbide dinitrate (ISDN) and its two active metabolites isosorbide-2-nitrate (IS-2-N) and isosorbide-5-nitrate (IS-5-N) were studied in 20 patients with normal and impaired renal function after repeated oral doses of standard 20 mg tablets ISDN t.i.d. Blood samples were taken in the steady-state on days 2 and 14, and the plasma concentrations were measured by electron capture capillary gas chromatography. We found a wide variation of pharmacokinetic parameters (AUC ss0–8 andt 1/2) of ISDN, IS-2-N, and IS-5-N in our patients. No correlation was detected between AUC ss0–8 ort 1/2 and the degree of renal insufficiency. No drug accumulation was observed after 14 days of administration.
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Abbreviations
- ISDN:
-
Isosorbide dinitrate
- IS-2-N:
-
Isosorbide-2-nitrate
- IS-5-N:
-
Isosorbide-5-nitrate
- CHD:
-
Coronary heart disease
- RI:
-
Renal insufficiency
- c max :
-
Maximum plasma concentration
- t max :
-
Time ofc max
- AUC ss0–8 :
-
Area under the curve at steady state (0–8)
- t 1/2 :
-
Elimination half-life.
References
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Evers, J., Bonn, R., Boertz, A. et al. Pharmacokinetics of isosorbide dinitrate, isosorbide-2-nitrate and isosorbide-5-nitrate in renal insufficiency after repeated oral dosage. Klin Wochenschr 67, 342–348 (1989). https://doi.org/10.1007/BF01741389
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DOI: https://doi.org/10.1007/BF01741389