Skip to main content
SpringerLink
Log in

Cysteamine-induced inhibition of mucosal and pancreatic alkaline secretion in rat duodenum

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

To determine the effect of cysteamine on the alkaline secretion by the duodenal epithelium, pancreas, and Brunner's glands in relation to the pathogenesis of duodenal ulceration, the alkaline secretion by various types of duodenal loops was comparatively studied. The results obtained were as follows: (1) Cysteamine significantly reduced both mucosal and pancreatobiliary alkaline secretion in the proximal duodenum of rats. (2) The ratio of contribution of pancreatobiliary alkaline secretion to total neutralization of acid in the proximal duodenum was 55.9% under continuous perfusion. (3) There was no significant difference between the amounts of alkali per unit volume of the proximal and distal duodenal loops. (4) The alkaline substance secreted by the proximal duodenal mucosa was confirmed to be the bicarbonate. From these findings, it has been concluded that the impairment of bicarbonate secretion by the mucosal epithelium of proximal duodenum, not by Brunner's glands, plays a causative role in cysteamine-induced duodenal ulceration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hörner MT: The effect of exclusion of the pancreatic secretion by evolution of the pancreatic ducts on the reaction of the duodenal content. Am J Dig Dis Nutr 2:295–298, 1935

    Google Scholar 

  2. McRoberts JW: The reaction of the duodenal content after exclusion of bile from the duodenum. Am J Dig Dis Nutr 2:293–294, 1935

    Google Scholar 

  3. Florey HW, Harding HE: Further observations on the secretion of Brunner's glands. J Pathol Bacteriol 39:255–276, 1934

    Google Scholar 

  4. Harrow B, Mazur A: Textbook of Biochemistry, 9th ed. Philadelphia, WB Saunders, 1966, p 233

    Google Scholar 

  5. Harmon JW, Woods M, Gurll NJ: Different mechanisms of hydrogen ion removal in stomach and duodenum. Am J Physiol 234:E692-E698, 1978

    Google Scholar 

  6. Ohe K, Okada Y, Fujiwara T, Inoue M, Miyoshi A: Cysteamine-induced inhibition of acid neutralization and the increase in hydrogen ion back diffusion in duodenal mucosa. Dig Dis Sci 27:250–256, 1982

    PubMed  Google Scholar 

  7. Isenberg JI, Smedfors R, Johansson C: Effect of graded doses of intraluminal H+, prostaglandin E2, and inhibition of endogenous prostaglandin synthesis on proximal duodenal bicarbonate secretion in anesthetized rat. Gastroenterology 88:303–307, 1985

    PubMed  Google Scholar 

  8. Selye H, Szabo S: Experimental model for production of perforating duodenal ulcers by cysteamine in the rat. Nature 244:458–459, 1973

    PubMed  Google Scholar 

  9. Szabo S: Animal model: Cysteamine-induced acute and chronic duodenal ulcer in the rat. Am J Pathol 93:273–276, 1978

    PubMed  Google Scholar 

  10. Isenberg JI, Selling JA, Hogan DL, Thomas JF, Koss MA: Duodenal ulcer (DU) patients have impaired proximal duodenal mucosal bicarbonate secretion. Gastroenterology 90:1472, 1986

    Google Scholar 

  11. Ohe K, Okada Y, Sanuki E, Fujiwara T, Fukushima T, Sumii K, Inoue M, Miyoshi A: Pathogenesis of cysteamineinduced duodenal ulcer.In Advance in Experimental Uler, S Umehara, H Ito (eds). Tokyo, 4th ICEU, 1981, pp 274–286

    Google Scholar 

  12. Adler RS, Gallagher GT, Szabo S: Duodenal ulcerogens cysteamine and propionitrile decrease duodenal neutralization of acid in the rat. Dig Dis Sci 28:716–723, 1983

    PubMed  Google Scholar 

  13. Briden S, Flemström G, Kivilaakso E: Cysteamine and propionitrile inhibit the rise of duodenal mucosal alkaline secretion in response to luminal acid in rats. Gastroenterology 88:295–302, 1985

    PubMed  Google Scholar 

  14. Tabata K, Jacobson ED, Chen M-H, Murphy RF, Joffe SN: Decrease in alkaline secretion during duodenal ulceration induced by mepyrizole in rats. Gastroenterology 87:396–401, 1984

    PubMed  Google Scholar 

  15. Schulze S, Pedersen NT, Jorgensen MJ, Mollmann K-M, Rune SJ: Association between duodenal bulb ulceration and reduced exocrine pancreatic function. Gut 24:781–783, 1983

    PubMed  Google Scholar 

  16. Borgström S, Arborelius M: Influence of a fatty acid on duodenal motility. Scand J Gastroenterol 10-599–601, 1975

    Google Scholar 

  17. Borgström S, Arborelius M: Duodenal motility pattern in duodenal ulcer disease. Scand J Gastroenterol 13:349–352, 1978

    PubMed  Google Scholar 

  18. Pihan G, Kline TJ, Hollenberg NK, Szabo S: Duodenal ulcerogens cysteamine and propionitrile induce gastroduodenal motility alterations in the rat. Gastroenterology 88:989–997, 1985

    PubMed  Google Scholar 

  19. Pihan G, Gallagher GT, Szabo S: Biliary and pancreatic secretions influence experimental duodenal ulcer without affecting gastric secretion in the rat. Dig Dis Sci 30:240–246, 1985

    PubMed  Google Scholar 

  20. Ohe K, Miura Y, Taoka Y, Nagamatsu Y, Yagita M: Cysteamine-induced inhibition of alkaline secretion by the duodenal mucosa and the pancreas, and the effect of secretin. Gastroenterology 88:1521, 1985

    Google Scholar 

  21. Garner A, Flemström G: Gastric HCO3 − secretion in the guinea pig. Am J Physiol 234:E531-E541, 1978

    Google Scholar 

  22. Henrickson FW, Worning H: The relation between the concentration of bicarbonate and protein in the pancreatic juice in the dog. J Physiol 187:285–289, 1966

    PubMed  Google Scholar 

  23. Pincus IJ: Embryology, anatomy, histology and anomalies of the pancreas.In Gastroenterology, Vol 3. HL Bockus (ed). Philadelphia, WB Saunders, 1976, pp 919–930

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Third Department of Internal Medicine, University of Environmental and Occupational Health, 1-1 Iseigaoka Yahata-Nishi-Ku, 807, Kitakyushu

    Keiji Ohe MD, DMSc, Yoshifumi Miura MD, Yoshio Taoka MD, DMSc, Yoshiomi Okada MD & Akima Miyoshi MD, DMSc

  2. Shizuoka Prefectural Medical Center, 4-27-1 Kita-Antoh, 420, Shizuoka, Japan

    Keiji Ohe MD, DMSc, Yoshifumi Miura MD, Yoshio Taoka MD, DMSc, Yoshiomi Okada MD & Akima Miyoshi MD, DMSc

Authors
  1. Keiji Ohe MD, DMSc
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoshifumi Miura MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshio Taoka MD, DMSc
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshiomi Okada MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Akima Miyoshi MD, DMSc
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ohe, K., Miura, Y., Taoka, Y. et al. Cysteamine-induced inhibition of mucosal and pancreatic alkaline secretion in rat duodenum. Digest Dis Sci 33, 330–337 (1988). https://doi.org/10.1007/BF01535759

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01535759

Key words

Search

Navigation