Abstract
The time course of light adaptation after intense light exposure is significantly delayed by alcohol, marijuana, and a combined dose of alcohol and marijuana. These effects were found in a double blind experiment, using 10 subjects. The experimental treatements were placebo, 0.75 ml/kg of 95% ethanol, 8 and 15 mg ofΔ 9 tetrahydrocannabinol (THC), and 0.75 ml/kg of 95% ethanol together with 15 mg of THC. The marijuana-induced delay in recovery is doserelated. Both drugs produce delayed recovery for at least 2 h after drug ingestion. The combined alcohol and marijuana treatment produces little more than the effect produced by either drug alone, suggesting some antagonism between the drugs — a suggestion supported by a significantly lower blood alcohol level for the alcohol dose when combined with marijuana than when taken alone.
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Adams, A. J., Brown, B.: Alcohol prolongs time course of glare recovery. Nature257, 481–483 (1975)
Adams, A. J., Brown, B., Flom, M. C.: Alcohol-induced changes in contrast sensitivity following high-intensity light exposure. Perception Psychophys.19, 219–225 (1976)
Adams, A. J., Brown, B., Flom, M. C., Jones, R. T., Jampolsky, A.: Alcohol and marijuana effects on static visual acuity. Am. J. Optom. Physiol. Opt.52, 729–735 (1975)
Anderson, P. F., Jackson, D. M., Cheser, G. B.: Interaction ofΔ 9 and cannabidiol on intestinal motility of mice. J. Pharm. Pharmacol.26, 136–137 (1974)
Carr, R. E., Henkind, P., Rothfield, N., Siegel, I.: Ocular toxicity of antimalarial drugs. Long term follow-up. Am. J. Ophthalmol.66, 738–744 (1968)
Frank, I. M., Hepler, R. S., Stier, S., Rickles, W. H., Ungerleider, J. T.: Marijuana, tobacco and functions affecting driving. Paper presented at the Annual Meeting of the American Psychiatric Association, Washington, D. C., May 3–7 (1971)
LeDain, G., ed.: Cannabis. A report of the commission of inquiry into the non-medical use of drugs. Ottawa: Information Canada 1972
Manno, J. E., Kiplinger, G. F., Scholtz, N., Forney, R. B.: The influence of alcohol and marihuana on motor and mental performance. Clin. Pharmacol. Ther.12, 202–211 (1971)
Raskin, N. H., Sligar, K. P., Steinberg, R. H.: Dark adaptation slowed by inhibitors of alcohol dehydrogenase in the albino rat. Brain Res.50, 496–500 (1973)
Severin, S. L., Tour, R. L., Kershaw, R. H.: Macular function and the photostress test 2. Arch. Ophthalmol.77, 163–167 (1967)
Siegel, S.: Nonparametric statistics for the behavioral sciences. New York: McGraw-Hill 1956
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Adams, A.J., Brown, B., Haegerstrom-Portnoy, G. et al. Marijuana, alcohol, and combined drug effects on the time course of glare recovery. Psychopharmacology 56, 81–86 (1978). https://doi.org/10.1007/BF00571413
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DOI: https://doi.org/10.1007/BF00571413