Summary
The thiocarbamic esters (L)ETC(EtOSCNHEt) and PTC (EtOSCNHPr) act as sulphur donors towards platinum halides, yielding the cis-[Pt(L)2Cl2], trans-[Pt(L)2Br2], [Pt(L)3X]X (X = Cl or Br) and [Pt(L)4]X2 (X = Cl, Br or I) complexes. By addition of n-hexane to platinum chloride solutions in pure ligands the 1∶6 adducts [Pt(L)4]-Cl2·2L have been isolated. The non-bonded ligand molecules are easily released to give the corresponding 1∶4 complexes. The compounds have been characterized by elemental analysis and spectroscopy. The 1∶4 and 1∶6 complexes decompose in benzene to form the 1∶3 species, except for [Pt(ETC)4]I2, which releases two ligand molecules to give trans-[Pt(ETC)2I2]. The 1∶2 and 1∶3 complexes have been tested for in vitro cytostatic activity against KB cells.
Similar content being viewed by others
References
J. Reedijk, A. M. J. Fichtinger-Schepman, A. T. van Oosterom and P. van de Putte, Structure and Bonding, 67, 53 (1987).
M. P. Hacker and J. D. Roberts in M. Nicolini (Ed.), Platinum and Other Metals Coordination Compounds in Cancer Chemotherapy, Martinus Nijhoff, Boston, 1988, p. 163.
M. Bruley-Rosset, I. Vergnon and G. Renoux, Int. J. Immunopharmacol., 8, 287 (1986).
R. F. Borch, P. C. Dedon, A. Gringeri and T. J. Montine in M. Nicolini (Ed.): Platinum and Other Metals Coordination Compounds in Cancer Chemotherapy, Martinus Nijhoff, Boston. 1988, p. 216.
L. Sindellari, G. Faraglia, B. Zarli, P. Cavoli, A. Furlani and V. Scarcia, Inorg. Chim. Acta, 46, 37 (1980).
G. Faraglia, L. Sindellari, B. Zarli and I. Agnoletti, Inorg. Chim. Acta, 58, 13 (1982).
G. Faraglia, L. Sindellari, L. Chiavegato and S. Sitran, Inorg. Chim. Acta, 76, L 103 (1983).
A. Furlani, V. Scarcia, G. Faraglia, L. Sindellari and B. Zarli, Inorg. Chim. Acta, 67, L 41 (1982).
G. Faraglia, L. Sindellari, L. Trinci, A. Furlani and V. Scarcia, Inorg. Chim. Acta, 106, 31 (1985).
A. Furlani, V. Scarcia, G. Faraglia, L. Sindellari, L. Trincia and M. Nicolini, Eur. J. Med. Chem.,-Chim. Ther., 21, 261 (1986).
D. A. Clemente, G. Faraglia, L. Sindellari and L. Trincia, J. Chem. Soc., Dalton Trans., 1823 (1987).
G. Faraglia and S. Sitran, Inorg. Chim. Acta, 176, 67 (1990).
G. Faraglia, F. Barbaro and L. Sindellari, Transition Met. Chem., 12, 457 (1987).
G. Faraglia and F. Barbaro, J. Coord. Chem., 19, 349 (1989).
B. Holmberg, J. Prakt. Chem., 71, 264 (1905).
B. Holmberg, Chem. Zentr., 1, 1926 (1930).
R. Bardi, A. M. Piazzesi, A. Del Pra and L. Trincia, Acta Crystallogr., Sect. C: 43, 1281 (1987).
R. Bardi, A. M. Piazzesi, A. Del Pra, M. Celeste, G. Faraglia and L. Trincia, Inorg. Chim. Acta, 102, 45 (1985).
H. Eagle, Proc. Soc. Exp. Biol. Med., 89, 362 (1955).
R. I. Geran, N. H. Greenberg, M. M. McDonald, A. M. Schumacher and B. J. Abbott, Cancer Chemother. Rep., 3, 1 (1972).
H. Eagle, Science, 130, 432 (1959).
Lj. Tusek-Bozik, I. Matijasic, G. Bocelli, G. Calestani, A. Furlani, V. Scarcia and A. Papaioannou, J. Chem. Soc., Dalton Trans., 195 (1991).
A. E. Lemire and J. C. Thompson, Can. J. Chem., 48, 824 (1970).
V. Cherchi, G. Faraglia, L. Sindellari and S. Sitran, Transition Met. Chem., 10, 76 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Faraglia, G., Sindellari, L., Cherchi, V. et al. Platinum-dihalide complexes with N-alkyl O-ethylthiocarbamates. Transition Met Chem 18, 45–50 (1993). https://doi.org/10.1007/BF00136048
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00136048