Abstract
Allergic skin inflammation such as atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. The anti-inflammatory effects of Apo-9′-fucoxanthinone, isolated from Sargassum muticum, have been described in many diseases, but the mechanism by which it modulates the immune system is poorly understood. In this study, the ability of Apo-9′-fucoxanthinone to suppress allergic reactions was investigated using a mouse model of atopic dermatitis. The Apo-9′-fucox-anthinone-treated group showed significantly decreased immunoglobulin E in serum. Also, Apo-9′-fucox-anthinone treatment resulted in a smaller lymph node size with reduced the thickness and length compared to the induction group. In addition, Apo-9′-fucoxanthinone inhibited the expression of interleukin-4, inter-feron-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. These results suggest that Apo-9′-fucoxanthinone may be a useful therapeutic strategy for treating chronic inflammatory diseases.
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Abbreviations
- AD:
-
Atopic dermatitis
- DNCB:
-
2, 4-dinitrochlorobenzene
- APO-9:
-
Apo-9′-fucoxanthinone
- IgE:
-
Immunoglobulin E
- PMA:
-
Phorbol 12-myristate 13-acetate.
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Han, SC., Kang, NJ., Yoon, WJ. et al. External Application of Apo-9′-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis. Toxicol Res. 32, 109–114 (2016). https://doi.org/10.5487/TR.2016.32.2.109
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DOI: https://doi.org/10.5487/TR.2016.32.2.109