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Human autologous mesenchymal stem cells with extracorporeal shock wave therapy for nonunion of long bones

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Abstract

Background: Currently, the available treatments for long bone nonunion (LBN) are removing of focus of infection, bone marrow transplantation as well as llizarov methods etc. Due to a high percentage of failures, the treatments are complex and debated. To develop an effective method for the treatment of LBN, we explored the use of human autologous bone mesenchymal stems cells (hBMSCs) along with extracorporeal Shockwave therapy (ESWT).

Materials and Methods: Sixty three patients of LBN were subjected to ESWT treatment and were divided into hBMSCs transplantation group (Group A, 32 cases) and simple ESWT treatment group (Group B, 31 cases).

Results: The patients were evaluated for 12 months after treatment. In Group A, 14 patients were healed and 13 showed an improvement, with fracture healing rate 84.4%. In Group B, eight patients were healed and 13 showed an improvement, with fracture healing rate 67.7%. The healing rates of the two groups exhibited a significant difference (P < 0.05). There was no significant difference for the callus formation after 3 months treatment (P > 0.05). However, the callus formation in Group A was significantly higher than that in the Group B after treatment for 6, 9, and 12 months (P < 0.05).

Conclusion: Autologous bone mesenchymal stems cell transplantation with ESWT can effectively promote the healing of long bone nonunions.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Tianjin Hospital, Hexi District, Tianjin, 300211, P. R. China

    Xin-Long Ma

  2. Department of Orthopaedic Surgery, The General Hospital of Chinese People’s Armed Police Force, Haidian District, Beijing, 100039, P. R. China

    Chuan Jiang &  Geng-Yan Xing

  3. Department of Immunology, Tianjin Medical University, Heping District, Tianjin, 300052, P. R. China

    Bo Zhang

  4. Department of Orthopaedic Surgery, The Affiliated Hospital of Logistics College of Chinese People’s Armed Police Force, Pingjin Hospital, Hedong District, Tianjin, 300162, P. R. China

    Shui-Tao Liu

  5. Department of Orthopaedic Surgery, The General Hospital of Tianjin Medical University, Tianjin, P. R. China

    Lei Zhai

Authors
  1. Lei Zhai
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  2. Xin-Long Ma
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  3. Chuan Jiang
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Correspondence to Geng-Yan Xing.

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This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Zhai, L., Ma, XL., Jiang, C. et al. Human autologous mesenchymal stem cells with extracorporeal shock wave therapy for nonunion of long bones. IJOO 50, 543–550 (2016). https://doi.org/10.4103/0019-5413.189602

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  • DOI: https://doi.org/10.4103/0019-5413.189602

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