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New Radionuclides for Personalized Medicine

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Bulletin of the Russian Academy of Sciences: Physics Aims and scope

Abstract

The study of the processes and mechanisms of the medium group mass nuclear systems formation (formed in reactions with protons) has both an important fundamental and practical significance. These tasks are especially important for the production of medical radionuclides, which are used for the effective early diagnosis and treatment of the various cancers. Combining the methods of radionuclide imaging with the methods of radionuclide therapy (therapy plus diagnostics—theranostics), it is possible to implement unique methods of non-surgical treatment of tumors with their precise visualization and minimal side effects. Therefore, in this work the experimental and theoretical studies of the nuclear reaction excitation functions with targets: 117Sn and 119Sn in the proton energy range of 6–18 MeV are carried out. Cross sections of the formation of antimony radionuclides are obtained for these reactions, and the mechanisms of such reactions are analyzed. Antimony radionuclides are promising for use in theranostics.

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ACKNOWLEDGMENTS

We are especially thankful to the staff of the MGC-20 cyclotron of V.G. Khlopin Radium Institute for allowing us to perform experimental studies.

Funding

This work was supported by the Russian Foundation for Basic Research, project no. 20-02-00295.

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Authors and Affiliations

  1. St. Petersburg State University, 199034, St. Petersburg, Russia

    V. I. Zherebchevsky, T. V. Lazareva, N. A. Maltsev, D. K. Nauruzbayev, D. G. Nesterov, N. A. Prokofiev, A. R. Rahmatullina & S. Yu. Torilov

  2. Khlopin Radium Institute, 194021, St. Petersburg, Russia

    I. E. Alekseev

Authors
  1. V. I. Zherebchevsky
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  2. I. E. Alekseev
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  3. T. V. Lazareva
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  4. N. A. Maltsev
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  5. D. K. Nauruzbayev
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  6. D. G. Nesterov
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  7. N. A. Prokofiev
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  8. A. R. Rahmatullina
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  9. S. Yu. Torilov
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Corresponding author

Correspondence to V. I. Zherebchevsky.

Additional information

Translated by L. Solovyova

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Zherebchevsky, V.I., Alekseev, I.E., Lazareva, T.V. et al. New Radionuclides for Personalized Medicine. Bull. Russ. Acad. Sci. Phys. 85, 1128–1135 (2021). https://doi.org/10.3103/S1062873821100282

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  • DOI: https://doi.org/10.3103/S1062873821100282

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