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PEG-Chitosan as a Perspective Stabilizing Agent for Liposomal Suspensions: The Influence of the Molecular Weight and Degree of PEGylation on the Physicochemical Properties of the Complex

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Moscow University Chemistry Bulletin Aims and scope

Abstract

The possibility of regulating the physicochemical properties (stability, size, and binding sites) of liposomal containers for drug delivery by selecting the molecular weight and degree of modification of PEG-chitosan is demonstrated. The effect of the regulation of the release of doxorubicin from liposomal containers depending on the properties of the polymer and pH is demonstrated.

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Abbreviations

CL:

cardiolipin

DPPtdCho:

dipalmitoylphosphatidylcholine

PEG:

polyethylene glycol

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, Moscow, 119991, Russia

    I. M. Le-Deygen & E. V. Kudryashova

Authors
  1. I. M. Le-Deygen
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  2. E. V. Kudryashova
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Correspondence to I. M. Le-Deygen.

Additional information

Original Russian Text © I.M. Le-Deygen, E.V. Kudryashova, 2018, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2018, No. 2, pp. 151–156.

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Le-Deygen, I.M., Kudryashova, E.V. PEG-Chitosan as a Perspective Stabilizing Agent for Liposomal Suspensions: The Influence of the Molecular Weight and Degree of PEGylation on the Physicochemical Properties of the Complex. Moscow Univ. Chem. Bull. 73, 69–73 (2018). https://doi.org/10.3103/S0027131418020074

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  • DOI: https://doi.org/10.3103/S0027131418020074

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