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Serum levels of sFas and sFasL in subjects with type 2 diabetes — the impact of arterial hypertension

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Aim

To evaluate the serum levels of sFas and sFasL in normotensive subjects with different degree of impairment of glucose tolerance as well as in type 2 diabetic patients with treated and treatment-naïve hypertension (AHT).

Material and methods

124 subjects (63 males and 61 females), of mean age 46,31±10,78 years are included in the study, divided in 5 age-matched groups: 19 subjects with type 2 diabetes (DM) and drug-controlled AHT; 30 subjects with type 2 DM and drug-naïve AHT; 30 normotensive subjects with type 2 DM; 26 normotensive subjects with prediabetes and 19 healthy controls. Serum sFas and sFasL levels are determined by highly sensitive enzyme immunoassay technique.

Results

No significant differences in sFas are observed among the studied groups. The levels of sFasL are decreased in normotensive subjects with type 2 DM (p<0,05), while subjects with prediabetes have intermediate values. In both hypertensive groups with DM sFasL levels are further decreased.

Conclusions

Serum sFas levels probably are not associated with the presence of impairment of glucose tolerance or AHT. Serum sFasL values tend to be decreased in subjects with impairment in glucose tolerance; further decrease is observed in hypertensive subjects with type 2 DM. Antihypertensive treatment does not influence the levels of sFasL.

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Authors and Affiliations

  1. Clinical Center of Endocrinology, Medical University, Sofia, 1431, Bulgaria

    Nikolay Stoynev, Georgi Kirilov & Tsvetalina Tankova

  2. New Bulgarian University, Sofia, 1618, Bulgaria

    Krassimir Kalinov

  3. Department of Physiology, Medical University, Sofia, Bulgaria

    Nikolay Stoynev

Authors
  1. Nikolay Stoynev
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  2. Krassimir Kalinov
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  3. Georgi Kirilov
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  4. Tsvetalina Tankova
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Correspondence to Nikolay Stoynev.

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Stoynev, N., Kalinov, K., Kirilov, G. et al. Serum levels of sFas and sFasL in subjects with type 2 diabetes — the impact of arterial hypertension. cent.eur.j.med 9, 704–708 (2014). https://doi.org/10.2478/s11536-013-0318-7

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  • DOI: https://doi.org/10.2478/s11536-013-0318-7

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