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Detection of Chlortetracycline Hydrochloride in Milk with a Solid SERS Substrate Based on Self-assembled Gold Nanobipyramids

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Abstract

This paper described how a high-yield, monodisperse Au nanobipyramids (Au NBs) sol was prepared by a seed-mediated method, and gold nanoparticles were assembled on the surface of a silicon wafer by self-assembly technology to obtain a solid SERS substrate. Scanning electron microscopy (SEM) showed that the average length of Au NBs was 34.31 nm, and the analysis enhancement factor (AEF) was approximately 7.3 × 105 with rhodamine 6G (R6G) used as a probe. SERS detection of chlortetracycline hydrochloride (CCH) in milk was performed utilizing the prepared Au NBs substrate, and the limit of detection was 0.01 mg/mL. In the range of 0.01–1 mg/mL, the mass concentration of CCH and the SERS signal intensity satisfied the linear relationship y = 258.467x + 150.501; the value of the correlation coefficient was 0.9785. In addition, the recovery of spiked samples fluctuated between 96.80 to 111.38%. These results proved that the method is simple and fast, and it is promising to be applied to the field detection of antibiotics in milk.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 31871873) and the Inner Mongolia Autonomous Region Natural Science Foundation of China (Grant No. 2018LH08055)

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Authors and Affiliations

  1. National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin, 150080, China

    Nan Li, Siqingaowa Han, Chen Zhang, Shuang Lin, Xuan-yu Sha & Wuliji Hasi

  2. College of Art and Sciences, Northeast Agricultural University, Harbin, 150030, China

    Nan Li

  3. Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao 028043, China

    Siqingaowa Han

Authors
  1. Nan Li
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  2. Siqingaowa Han
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  3. Chen Zhang
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  4. Shuang Lin
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  5. Xuan-yu Sha
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  6. Wuliji Hasi
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Correspondence to Siqingaowa Han or Wuliji Hasi.

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Li, N., Han, S., Zhang, C. et al. Detection of Chlortetracycline Hydrochloride in Milk with a Solid SERS Substrate Based on Self-assembled Gold Nanobipyramids. ANAL. SCI. 36, 935–940 (2020). https://doi.org/10.2116/analsci.19P476

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  • DOI: https://doi.org/10.2116/analsci.19P476

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