A Novel Sensitive Doxorubicin Hydrochloride Electrochemical Sensor Based on a Nickel Hexacyanoferrate/Ni-Al-LDH Modified Gold Electrode

Abstract

A highly sensitive and selective electrochemical sensor has been fabricated by the electrodepositing of nickel hexacyanoferrate (NiHCF) on a Ni-Al layered double hydroxides (Ni-Al-LDH) modified Au electrode for the quantification of doxorubicin hydrochloride (DOX). The characterization of synthesized nanomaterials has been conducted by scanning electron microscopy, energy dispersive X-ray spectroscopy and electrochemical methods. The synergistic effect of NiHCF and Ni-Al-LDH not only excellently improves the performance of DOX electro-reduction, but also promotes electron transfer between DOX and the NiHCF/Ni-Al-LDH/Au sensor. The differential pulse voltammetric response of the NiHCF/Ni-Al-LDH/Au sensor shows a linear relationship with the concentration of DOX in the range of 1.0 × 10⁻⁸ - 6.2 × 10⁻⁶ mol L⁻¹, a limit of detection of 1.9 × 10⁻⁹ mol L⁻¹ (S/N=3) and a sensibility of 14.71 A mol L⁻¹ cm⁻². The developed sensor exhibits good sensitivity, reproducibility, anti-interference and a long-term stability property. Furthermore, the NiHCF/Ni-Al-LDH/Au sensor has been successfully applied to determine DOX in biological samples and human blood serum samples.