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In Vivo Imaging Technology of Transplanted Stem Cells Using Quantum Dots for Regenerative Medicine

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Abstract

Quantum dots (QDs) have excellent fluorescence properties in comparison to traditional fluorescence probes. Thus, the optical application of QDs is rapidly expanding to each field of analytical chemistry. In this review paper, we reviewed the application of QDs to regenerative medicine, especially stem cell transplantation therapy. The labeling of stem cells using QDs composed of semiconductor materials in combination with a chemical substance, poly-cationic liposome and cell penetrating peptide is reported. In addition, the influence of QD labeling on the pluripotency of stem cells is also reported. Finally, the in vivo imaging of transplanted stem cells in mice by QDs emitting fluorescence in the near-infrared region, which can be detected by in vivo fluorescence imaging systems such as IVIS and SAI-1000, is described. The future prospects for stem cell imaging technology by QDs are also discussed.

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Acknowledgments

This paper was mainly supported by the Japan Agency for Medical Research and Development (AMED) through its “Research Center Network for Realization of Regenerative Medicine” and partially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Numbers JP16K13646 and JP17H02731. We appreciate the help of

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Authors and Affiliations

  1. Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan

    Hiroshi Yukawa & Yoshinobu Baba

  2. ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan

    Hiroshi Yukawa & Yoshinobu Baba

  3. Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan

    Yoshinobu Baba

  4. Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, 761-0395, Japan

    Yoshinobu Baba

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  1. Hiroshi Yukawa
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Correspondence to Hiroshi Yukawa or Yoshinobu Baba.

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Yukawa, H., Baba, Y. In Vivo Imaging Technology of Transplanted Stem Cells Using Quantum Dots for Regenerative Medicine. ANAL. SCI. 34, 525–532 (2018). https://doi.org/10.2116/analsci.17R005

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  • DOI: https://doi.org/10.2116/analsci.17R005

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