Abstract
Diabetic nephropathy (DN) is currently the most common complication of diabetes. It is considered to be one of the leading causes of end-stage renal disease (ESRD) and affects many diabetic patients. The pathogenesis of DN is extremely complex and has not yet been clarified; however, in recent years, increasing evidence has shown the important role of innate immunity in DN pathogenesis. Pattern recognition receptors (PRRs) are important components of the innate immune system and have a significant impact on the occurrence and development of DN. In this review, we classify PRRs into secretory, endocytic, and signal transduction PRRs according to the relationship between the PRRs and subcellular compartments. PRRs can recognize related pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), thus triggering a series of inflammatory responses, promoting renal fibrosis, and finally causing renal impairment. In this review, we describe the proposed role of each type of PRRs in the development and progression of DN.
摘要
目的
阐述不同类型的模式识别受体(PRR)和糖尿病肾病(DN)之间的关系,以提供治疗DN 的新方 法和策略.
摘要
DN 是目前糖尿病最常见的并发症.它被认为是 终末期肾病(ESRD)的主要原因之一,并影响 许多糖尿病患者.DN 的发病机制极为复杂,且 尚未阐明,但近年来,越来越多的证据表明先天 免疫在DN 发病机制中起到了重要作用.PRR 是 先天免疫系统的重要组成部分,对DN 的发生和 发展具有重要影响.在本综述中,我们根据PRR 与亚细胞区室之间的关系将PRR 分为分泌型、内 吞型和信号转导型三种类型.PRR 可以识别相关 的病原体相关分子模式(PAMP)和危险相关分 子模式(DAMP),从而触发一系列炎症反应, 促进肾纤维化,最终导致肾功能损害.此外,我 们还描述了各种类型的PRR在DN的发生和发展 中的作用.
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Zhi-feng ZHOU and Lei JIANG set up the theme and the frame of this review, wrote and edited the manuscript. Qing ZHAO, Yu WANG, and Jing ZHOU performed the references collection and selection. Jin-lei LV and Qin-kai CHEN contributed the design and revision of the manuscript. All authors have read and approved the final manuscript.
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Zhi-feng ZHOU, Lei JIANG, Qing ZHAO, Yu WANG, Jing ZHOU, Qin-kai CHEN, and Jin-lei LV declare that they have no conflict of interest.
This article does not contain any studies with human or animal subjects performed by any of the authors.
Project supported by the National Natural Science Foundation of China (Nos. 81060063 and 81660129)
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Zhou, Zf., Jiang, L., Zhao, Q. et al. Roles of pattern recognition receptors in diabetic nephropathy. J. Zhejiang Univ. Sci. B 21, 192–203 (2020). https://doi.org/10.1631/jzus.B1900490
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DOI: https://doi.org/10.1631/jzus.B1900490