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Activity of metalloproteinases and adiponectin in obese patients— a possible factor of incisional hernias after bariatric procedures

肥胖患者体内金属蛋白酶和脂联素的活性——肥胖手术后造成切口疝的可能因素

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Abstract

Purpose

Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls.

Materials and methods

The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA).

Results

A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group.

Conclusions

The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.

摘要

目的

主要研究病态肥胖患者与正常人血清中金属蛋白 酶2(MMP-2)、MMP-9、MMP-13 和脂联素的 浓度。

创新点

建立血清中MMP-2、MMP-9、MMP-13 和脂联 素的浓度与肥胖和切口疝的关系。

方法

参与实验的人员为进行肥胖手术的患者和不进行 肥胖手术的患者,并将他们分为两组:I(体重 指数(BMI)≥35 kg/m2,n=40)和II (BMIlt;25 kg/m2, n=30),并使用酶联免疫吸附实验测定受试人员 体内血清中MMP-2、MMP-9、MMP-13 和脂联 素的浓度。

结论

MMP-2 的浓度在肥胖组中更高,且在两组血清 中有显著性差异。虽然MMP-9 的浓度在肥胖组 中更高,但是两组之间没有显著性差异。MMP-13 在两组间没有差异。血清中脂联素的浓度在非肥 胖组更高,但无显著性差异。因此,血清中 MMP-2和MMP-9的浓度在肥胖人群中与更高的 切口疝发病率有关。

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Authors and Affiliations

  1. Ludwik Rydygier College of Medicine in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland

    Wojciech Szczęsny, Magdalena Kuligowska-Prusińska, Stanisław Dąbrowiecki, Jakub Szmytkowski, Adrian Reśliński & Maciej Słupski

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  1. Wojciech Szczęsny
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  2. Magdalena Kuligowska-Prusińska
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  3. Stanisław Dąbrowiecki
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Correspondence to Adrian Reśliński.

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Szczęsny, W., Kuligowska-Prusińska, M., Dąbrowiecki, S. et al. Activity of metalloproteinases and adiponectin in obese patients— a possible factor of incisional hernias after bariatric procedures. J. Zhejiang Univ. Sci. B 19, 65–70 (2018). https://doi.org/10.1631/jzus.B1600383

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  • DOI: https://doi.org/10.1631/jzus.B1600383

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