Skip to main content
SpringerLink
Log in

Size-Tunable Magnetofluorescent Nanoparticles as In Vivo Imaging

  • Published:
MRS Online Proceedings Library Aims and scope

Abstract

Magnetic/fluorescent (magnetofluorescent) materials have become one of the most important tools in the imaging modality in vivo using magnetic resonance imaging (MRI) and fluorescence imaging. We succeeded in fabricating magnetofluorescent nanoparticles (MFNPs) consisting of silicon/magnetite composite nanoparticles. Our unique synthetic approach can control simultaneously the magnetic and fluorescence behaviors by varying the particle size, demonstrating the superparamagnetic behavior and green fluorescence for the MFNPs having mean diameter of 3.0 nm, and the ferromagnetic behavior without fluorescence for the MFNPs having mean diameter more than 5.0 nm. More intriguingly, the MFNPs with superparamagnetism can detect green fluorescence even after the magnetic guidance of MFNPs by the commercial neodymium magnet. Additionally, the MFNPs having two magnetic behaviors also possess good biocompatibility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J.-H. Park, G. Maltzahn, E. Ruoslahti, S. N. Bhatia, and M. J. Sailor, Angew. Chem. Int. Ed. 47, 7284–7288 (2008).

    Article  CAS  Google Scholar 

  2. C.-W. Lai, Y.-H. Wang, C.-H. Lai, M.-J. Yang, C.-Y. Chen, P.-T- Chou, C.-S. Chan, Y. Chi, Y.-C. Chen, and J.-K. Hsiao, Small 4, 218–224 (2008).

    Article  CAS  Google Scholar 

  3. N.-H. Cho, T.-C. Cheong, J. H. Min, J. H. Wu, S. J. Lee, D. Kim, J. S. Yang, S. Kim, Y. K. Kim, and S.-Y. Seong, Nat. Nanotechnol. 6, 675–682 (2011).

    Article  CAS  Google Scholar 

  4. K. Sato, S. Yanagisawa, A. Funakubo, Y. Fukui, K. Hirakuri, and T. Higami, Mater. Res. Soc. Symp. Proc. 958, 0958–L10–19 (2007).

  5. K. Fujioka, M. Hiruoka, K. Sato, N. Manabe, R. Miyasaka, S. Hanada, A. Hoshino, R. D. Tilley, Y. Manome, K. Hirakuri, and K. Yamamoto, Nanotechnology 19, 415102 (2008).

    Article  Google Scholar 

  6. K. Sato, K. Niino, N. Fukata, K. Hirakuri, and Y. Yamauchi, Nanotechnology 20, 365207 (2009).

    Article  Google Scholar 

  7. M. Hiruoka, K. Sato, and K. Hirakuri, J. Appl. Phys. 102, 024308 (2007).

    Article  Google Scholar 

  8. Z.-J. Zhou, and J.-J. Yan, J. Magn. Magn. Mater. 115, 87–98 (1992).

    Article  CAS  Google Scholar 

  9. R. Bardhan, W. Chen, C. P. Torres, M. Bartels, R. M. Huschka, L. L. Zhao, E. Morosan, R. G. Pautler, A. Joshi, and N. J. Halas, Adv. Funct. Mater. 19, 3901–3909 (2009).

    Article  CAS  Google Scholar 

  10. K. Sato, T. Izumi, M. Iwase, Y. Show, H. Morisaki, T. Yaguchi, and T. Kamino, Appl. Surf. Sci. 216, 376–381 (2003).

    Article  CAS  Google Scholar 

  11. C. Hui, C. Shen, J. Tian, L. Bao, H. Ding, C. Li, Y. Tian, X. Shi, and H.-J. Gao, Nanoscale 3, 701–705 (2011).

    Article  CAS  Google Scholar 

  12. M. M. Wu, Y. Shen, F. Gu, Y. A. Xie, J. C. Zhang, and L. J. Wang, J. Sol-Gel. Sci. Technol. 53, 470–474 (2010).

    Article  CAS  Google Scholar 

  13. J.-H. Park, G. V. Maltzahn, E. Ruoslahti, S. N. Bhatia, M. J. Sailor, Angew. Chem., Int. Ed. 47, 7284–7288 (2008).

    Article  CAS  Google Scholar 

  14. A.-H. Lu, E. L. Salabas, F. Schuth, Angew. Chem., Int. Ed. 46, 1222–1244 (2007).

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work was partially supported by the research grant from the Konica Minolta Imaging Science Foundation, and the research grant from the Iketani Science and Technology Foundation.

Author information

Authors and Affiliations

  1. Department of Electrical and Electronic Engineering, Tokyo Denki University, 5 Senju-Asahi-cho, Adachi-ku, Tokyo, 120-8551, Japan

    Keisuke Sato & Kenji Hirakuri

  2. International Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan

    Keisuke Sato & Naoki Fukata

  3. Department of Molecular Cell Biology, Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan

    Kouki Fujioka & Yoshinobu Manome

  4. Magnetic Materials Center, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki, 305-0047, Japan

    Hiroaki Sukegawa

  5. Materials Analysis Station, National Institute for Materials Science, 1-2-1 Sengen, Tsukuba, Ibaraki, 305-0047, Japan

    Hideo Iwai

Authors
  1. Keisuke Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kenji Hirakuri
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kouki Fujioka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yoshinobu Manome
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroaki Sukegawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hideo Iwai
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Naoki Fukata
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sato, K., Hirakuri, K., Fujioka, K. et al. Size-Tunable Magnetofluorescent Nanoparticles as In Vivo Imaging. MRS Online Proceedings Library 1660, 7–12 (2014). https://doi.org/10.1557/opl.2014.394

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1557/opl.2014.394

Search

Navigation