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Associations and Potential Multiple Mechanisms between Subjective Hearing Loss and Cognitive Impairment

  • Original Research
  • Published:
The Journal of Prevention of Alzheimer's Disease Aims and scope Submit manuscript

Abstract

Background

Subjective hearing loss (SHL) refers to an individual’s self-assessment of their hearing loss. The association and underlying mechanisms between SHL and cognitive impairment still necessitate elucidation.

Objectives

To validate potential mechanisms between SHL and cognitive impairment.

Design

Cross-section.

Setting

Shanghai, China.

Participants

A total of 2369 individuals from communities and the cognitive disorder clinic.

Measurements

All participants were subjected to a comprehensive neuropsychological assessment, encompassing the Hearing Handicap Inventory for the Elderly-Screening Version (HHIE-S). The participants’ brain β-amyloid (Aβ) deposition status, plasma biomarkers associated with Alzheimer’s disease (AD), and cardiovascular risk factors were also collected.

Results

In individuals with a heightened SHL, elevated HHIE-S score was linked to diminished cognitive and daily functioning as well as heightened levels of depressed mood. This correlation was observed in auditory memory performance but not in visual memory. The influence of SHL on cognitive function was mediated by depressed mood. SHL was associated with diabetes and smoking, whereas cognitive function was associated with hyperlipidemia and alcohol consumption. In individuals with positive brain Aβ deposition, SHL demonstrated associations with cognitive function independent of plasma Aβ42/40 ratio, P-tau181, neurofilament light chain, and APOE allele status.

Conclusion

SHL has an independent effect on cognitive impairment. The findings do no provide evidence for the common cause mechanism. Instead, the findings support the presence of a cognitive resource mechanism and an impoverished environment mechanism, along with the potential for a pathological interaction mechanism.

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Data Availability: The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgments

This study was funded by the National Natural Science Foundation of China (82171198), Shanghai Municipal Science and Technology Major Project (2018SHZDZX01), Shanghai Municipal Health Commission (202140042), and Guangdong Provincial Key S&T Program (2018B030336001). We would like to thank Jie-Hua Zhu, Xian-Qing Xie, and Yun Yang for their help with neuropsychological tests.

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  1. Liang Cui and You-Yi Tu contributed equally to this work

Authors and Affiliations

  1. Department of Gerontology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, 200233, China

    L. Cui, Y.-Y. Tu, Z. Zhang & Qi-Hao Guo

  2. Faculty of Medicine, The University of Queensland, Brisbane, Australia

    Y.-H. Guo

  3. Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, 518 East Wuzhong Road, Shanghai, 200040, China

    Y.-H. Guan & Fang Xie

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Contributions

Author Contributions: LC and QHG contributed to the conception and design of the study; YYT, ZZ, YHG, FX, and QHG contributed to the acquisition and analysis of data; LC and YHG contributed to drafting the text and preparing the figures. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Fang Xie or Qi-Hao Guo.

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Conflict of interest: The authors declare that they have no conflict of interest.

Ethical standards: The study was reviewed and approved by the Ethics Committee of Shanghai Sixth People’s Hospital (approval number 2019-032). It was performed in accordance with the principles of the Declaration of Helsinki. All participants provided written informed consent to participate in the study.

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How to cite this article: L. Cui, Y.-Y. Tu, Z. Zhang, et al. Associations and Potential Multiple Mechanisms between Subjective Hearing Loss and Cognitive Impairment. J Prev Alz Dis 2024; https://doi.org/10.14283/jpad.2024.62

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Cui, L., Tu, YY., Zhang, Z. et al. Associations and Potential Multiple Mechanisms between Subjective Hearing Loss and Cognitive Impairment. J Prev Alzheimers Dis (2024). https://doi.org/10.14283/jpad.2024.62

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