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Home Recovery After Mastectomy: Review of Literature and Strategies for Implementation American Society of Breast Surgeons Working Group

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Practices regarding recovery after mastectomy vary significantly, including overnight stay versus discharge same day. Expanded use of Enhanced Recovery After Surgery (ERAS) algorithms and the recent COVID pandemic have led to increased number of patients who undergo home recovery after mastectomy (HRAM).

Methods

The Patient Safety Quality Committee of the American Society of Breast Surgeons created a multispecialty working group to review the literature evaluating HRAM after mastectomy with and without implant-based reconstruction. A literature review was performed regarding this topic; the group then developed guidance for patient selection and tools for implementation.

Results

Multiple, retrospective series have reported that patients discharged day of mastectomy have similar risk of complications compared with those kept overnight, including risk of hematoma (0-5.1%). Multimodal strategies that improve nausea and analgesia improve likelihood of HRAM. Patients who undergo surgery in ambulatory surgery centers and by high-volume breast surgeons are more likely to be discharged day of surgery. When evaluating unplanned return to care, the only significant factors are African American race and increased comorbidities.

Conclusions

Review of current literature demonstrates that HRAM is a safe option in appropriate patients. Choice of method of recovery should consider patient factors, such as comorbidities and social situation, and requires input from the multidisciplinary team. Preoperative education regarding pain management, drain care, and after-hour access to medical care are crucial components to a successful program. Additional investigation is needed as these programs become more prevalent to assess quality measures such as unplanned return to care, complications, and patient satisfaction.

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References

  1. Warren JA, Potosky AL, Klabunde CN, et al. Trends and outcomes of outpatient mastectomy in elderly women. JNCI. 1998;90(11):833–40.

    Article  CAS  PubMed  Google Scholar 

  2. Centers for Disease Control. 2000. https://stacks.cdc.gov/view/cdc/41564/cdc_41564_DS1. Accessed 3 July 2021.

  3. Arsalani-Zadeh R, ELFadl D, Yassin N, MacFie J. Evidence-based review of enhancing postoperative recovery after breast surgery. Br J Surg. 2011;98(2):181–96.

    Article  CAS  PubMed  Google Scholar 

  4. Grant MC, Pio Roda CM, Canner JK, et al. The impact of anesthesia-influenced process measure compliance on length of stay: results from an enhanced recovery after surgery for colorectal surgery cohort. Anesth Analg. 2019;128(1):68–74.

    Article  PubMed  Google Scholar 

  5. Smith TW Jr, Wang X, Singer MA, Godellas CV, Vaince FT. Enhanced recovery after surgery: a clinical review of implementation across multiple surgical subspecialties. Am J Surg. 2020;219(3):530–4.

    Article  PubMed  Google Scholar 

  6. Rojas KE, Fortes TA, Manasseh DM, Andaz C, Borgen PI. Mastectomy is no longer an indication for postoperative opioid prescription at discharge. Am J Surg. 2019;218(4):700–5.

    Article  PubMed  Google Scholar 

  7. Rojas KE, Manasseh DM, Flom PL, et al. A pilot study of a breast surgery Enhanced Recovery After Surgery (ERAS) protocol to eliminate narcotic prescription at discharge. Breast Cancer Res Treat. 2018;171(3):621–6.

    Article  PubMed  Google Scholar 

  8. Steiner CA, Weiss AJ, Barrett ML, Fingar KR, Davis PH. Trends in Bilateral and Unilateral Mastectomies in Hospital Inpatient and Ambulatory Settings, 2005–2013. HCUP Statistical Brief #201. February 2016.

  9. Cordeiro E, Jackson T, Cil T. Same-day major breast cancer surgery is safe: an analysis of short-term outcomes using NSQIP data. Ann Surg Oncol. 2016;23:2480–6.

    Article  PubMed  Google Scholar 

  10. Bartlett DL, Howe JR, Chang G, et al. Management of cancer surgery cases during the COVID-19 pandemic: considerations. Ann Surg Oncol. 2020;27:1717–20.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Cortina CS, Ward EP, Kong AL. The consideration for outpatient mastectomy during the Covid-19 global pandemic. Am J Surg. 2021. https://doi.org/10.1016/j.amjsurg.2020.12.043.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Vuong B, Dusendang JR, Chang SB, et al. Outpatient mastectomy: factors influencing patient selection of predictors of return to Care. J Am Coll Surg. 2020;232(1):35–44.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Jogerst K, Thomas O, Kosiorek HE, et al. Same-day discharge after mastectomy: breast cancer surgery in the era of ERAS®. Ann Surg Oncol. 2020;27(9):3436–45.

    Article  PubMed  Google Scholar 

  14. Specht M, Sobti N, Rosado N, et al. High-efficiency same-day approach to breast reconstruction during the COVID-19 crisis. Breast Cancer Res Treat. 2020;182(3):679–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Hammond JB, Thomas O, Jogerst K, et al. Same-day discharge is safe and effective after implant-based breast reconstruction. Ann Plast Surg. 2021;87(2):144–9.

    Article  CAS  PubMed  Google Scholar 

  16. Schwartz JC. Mastectomy and prepectoral reconstruction in an ambulatory surgery center reduces major infections complication rates. PRS Global Open. 2020;8(7):e2960.

    PubMed  PubMed Central  Google Scholar 

  17. Keehn AR, Olson DW, Dort JC, et al. Same-day surgery for mastectomy patients in Alberta: a perioperative care pathway and quality improvement initiative. Ann Surg Oncol. 2019;26(10):3354–60.

    Article  PubMed  Google Scholar 

  18. Dumestre DO, Redwood J, Webb CE, Temple-Oberle C. Enhanced Recovery After Surgery (ERAS) protocol enables safe same-day discharge after alloplastic breast reconstruction. Plast Surg (Oakv). 2017;25(4):249–54.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Oxley PJ, McNeely C, Janzen R, et al. Successful same day discharge after immediate post-mastectomy alloplastic breast reconstruction: a single tertiary centre retrospective audit. J Plast Rec Aesth Surg. 2020;73:1068–74.

    Article  Google Scholar 

  20. Bakeer MA, Coker C, Atamian E, Yoo D, Torabi R, Riker A. A single-institution case series of outpatient same-day mastectomy: implementation of a quality improvement project and initiative for enhanced recovery after surgery. Ochsner J. 2020;20(4):388–93.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Qin C, Antony AK, Aggarwal A, Jordan S, Gutowski KA, Kim JY. Assessing outcomes and safety of inpatient versus outpatient tissue expander immediate breast reconstruction. Ann Surg Oncol. 2015;22:3724–9.

    Article  PubMed  Google Scholar 

  22. Marla S, Stallard S. Systematic review of day surgery for breast cancer. Int J Surg. 2009;7:318–23.

    Article  CAS  PubMed  Google Scholar 

  23. Brenin DR, Dietz JR, Baima J, et al. Pain management in breast surgery: recommendations of a multidisciplinary expert panel—the American Society of Breast Surgeons. Ann Surg Oncol. 2020;27(12):4588–602.

    Article  PubMed  Google Scholar 

  24. Manahan MA, Basdag B, Kalmar CL, et al. Risk of severe and refractory postoperative nausea and vomiting in patients undergoing DIEP flap breast reconstruction. Microsurgery. 2014;34:112–21.

    Article  PubMed  Google Scholar 

  25. Gan TJ, Belani KG, Bergese S, et al. Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2020;131(2):411–48.

    Article  PubMed  Google Scholar 

  26. Gupta P, Jain S. Postoperative nausea and vomiting prophylaxis: a comparative study of ondansetron, granisetron and granisetron and dexamethasone combination after modified radical mastectomy. Saudi J Anaesth. 2014;8(Suppl 1):S67-71.

    PubMed  PubMed Central  Google Scholar 

  27. Schraag S, Pradelli L, Alsaleh AJO, et al. Propofol vs inhalational agents to maintain general anaesthesia in ambulatory and in-patient surgery: a systematic review and meta-analysis. BMC Anesthesiol. 2018;18(162):1–9.

    Google Scholar 

  28. Barker JC, DiBartola K, Wee C, et al. Preoperative multimodal analgesia decreases postanesthesia care unit narcotic use and pain scores in outpatient breast surgery. Plast Reconstr Surg. 2018;142:443e–50e.

    Article  CAS  PubMed  Google Scholar 

  29. De Oliveira GS, Rodes ME, Bialek J, Kendall MC, McCarthy RJ. Single dose systemic acetaminophen to improve patient reported quality of recovery after ambulatory segmental mastectomy: a prospective, randomized, double-blinded, placebo controlled, clinical trial. Breast J. 2018;24(3):240–4.

    Article  PubMed  CAS  Google Scholar 

  30. Plunkett A, Haley C, McCoart A, et al. A preliminary examination of the comparative efficacy of intravenous vs oral acetaminophen in the treatment of perioperative pain. Pain Med. 2017;18:2466–73.

    PubMed  Google Scholar 

  31. van der Westhuizen J, Kuo PY, Reed PW, Holder K. Randomised controlled trial comparing oral and intravenous paracetamol (acetaminophen) plasma levels when given as preoperative analgesia. Anaesth Intensive Care. 2011;39:242–6.

    Article  PubMed  Google Scholar 

  32. Bourgeois FT, Graham DA, Kesselheim AS, Randolph AG. Cost implications of escalating intravenous acetaminophen use in children. JAMA Pediatr. 2019;173:489–91.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Mitchell A, McCrea P, Inglis K, Porter G. A randomized, controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine (Tylenol 3) after outpatient breast surgery. Ann Surg Oncol. 2012;19(12):3792–800. https://doi.org/10.1245/s10434-012-2447-7.

    Article  PubMed  Google Scholar 

  34. Parsa AA, Sprouse-Blum AS, et al. Combined preoperative use of celecoxib and gabapentin in the management of postoperative pain. Aesthetic Plast Surg. 2009;33:98–103.

    Article  PubMed  Google Scholar 

  35. Sun T, Sacan O, White PF, Coleman J, Rohrich RJ, Kenkel JM. Perioperative versus postoperative celecoxib on patient outcomes after major plastic surgery procedures. Anesth Analg. 2008;106:950–8.

    Article  CAS  PubMed  Google Scholar 

  36. Walker NJ, Jones VM, Kratky L, Chen H, Runyan CM. Hematoma risks of nonsteroidal anti-inflammatory drugs used in plastic surgery procedures: a systematic review and meta-analysis. Ann Plast Surg. 2019;82:S437–45.

    Article  CAS  PubMed  Google Scholar 

  37. Rojas KE, Fortes TA, Flom P, Manasseh DM, Andaz C, Borgen P. Intraoperative ketorolac use does not increase the risk of bleeding in breast surgery. Ann Surg Oncol. 2019;26:3368–73.

    Article  PubMed  Google Scholar 

  38. Nguyen BN, Barta RJ, Stewart CE, Wheelwright M, Heinrich CA. Ketorolac for patients undergoing implant-based breast reconstruction: impact on hospital length of stay and postoperative narcotic use. Aesthet Surg J. 2020;40:174–9.

    Article  PubMed  Google Scholar 

  39. Bourazani M, Papageorgiou E, Zarkadas G, et al. The role of muscle relaxants: spasmolytic (thiocochlicoside) in postoperative pain management after mastectomy and breast reconstruction. Asian Pac J Cancer Prev. 2019;20:743–9.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Amr YM, Yousef AA. Evaluation of efficacy of the perioperative administration of venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain. 2010;26:381–5.

    Article  PubMed  Google Scholar 

  41. Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, Dahl JB. A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology. 2002;97:560–4.

    Article  CAS  PubMed  Google Scholar 

  42. Grover VK, Mathew PJ, Yaddanapudi S, Sehgal S. A single dose of preoperative gabapentin for pain reduction and requirement of morphine after total mastectomy and axillary dissection: randomized placebo-controlled double-blind trial. J Postgrad Med. 2009;55:257–60.

    Article  CAS  PubMed  Google Scholar 

  43. Hah J, Mackey SC, Schmidt P, et al. Effect of perioperative gabapentin on postoperative pain resolution and opioid cessation in a mixed surgical cohort: a randomized clinical trial. JAMA Surg. 2018;153:303–11.

    Article  PubMed  Google Scholar 

  44. Jiang Y, Li J, Lin H, et al. The efficacy of gabapentin in reducing pain intensity and morphine consumption after breast cancer surgery: a meta-analysis. Med Baltim. 2018;97:e11581.

    Article  CAS  Google Scholar 

  45. Rai AS, Khan JS, Dhaliwal J, et al. Preoperative pregabalin or gabapentin for acute and chronic postoperative pain among patients undergoing breast cancer surgery: a systematic review and meta-analysis of randomized controlled trials. J Plast Reconstr Aesthet Surg. 2017;70:1317–28.

    Article  PubMed  Google Scholar 

  46. Kim SY, Song JW, Park B, Park S, An YJ, Shim YH. Pregabalin reduces postoperative pain after mastectomy: a double-blind, randomized, placebo-controlled study. Acta Anaesthesiol Scand. 2011;55:290–6.

    Article  CAS  PubMed  Google Scholar 

  47. Verret M, Lauzier F, Zarychanski R, et al. Perioperative use of gabapentinoids for the management of postoperative acute pain: a systematic review and meta-analysis. Anesthesiology. 2020;133:265–79.

    Article  PubMed  Google Scholar 

  48. Hamilton TW, Athanassoglou V, Mellon S, et al. Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain. Cochrane Database Syst Rev. 2017;2(2):CD011419.

    PubMed  Google Scholar 

  49. Woodworth GE, Ivie RMJ, Nelson SM, Walker CM, Maniker RB. Perioperative breast analgesia: a qualitative review of anatomy and regional techniques. Reg Anesth Pain Med. 2017;42(5):609–31.

    Article  PubMed  Google Scholar 

  50. Cheng GS, Ilfeld BM. A review of postoperative analgesia for breast cancer surgery. Pain Manag. 2016;6(6):603–18.

    Article  PubMed  Google Scholar 

  51. Rao R, Jackson RS, Rosen B, et al. Pain control in breast surgery: survey of current practice and recommendations for optimizing management—American Society of Breast Surgeons Opioid/Pain Control Workgroup. Ann Surg Oncol. 2020;27:985–90.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Layeeque R, Hochberg J, Siegel E, et al. Botulinum toxin infiltration for pain control after mastectomy and expander reconstruction. Ann Surg. 2004;240(4):608–13.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Antony AK, Poirier J, Madrigrano A, Kopkash KA, Robinson EC. Evolution of the surgical technique for “Breast in a Day” direct-to-implant breast reconstruction: transitioning from dual-plane to prepectoral implant placement. Plast Reconstr Surg. 2019;143(6):1547–56.

    Article  CAS  PubMed  Google Scholar 

  54. Sigalove S, Maxwell GP, Sigalove NM, et al. Prepectoral implant-based breast reconstruction: rationale, indications, and preliminary results. Plast Reconstr Surg. 2017;139(2):287–94.

    Article  CAS  PubMed  Google Scholar 

  55. Casella D, Kaciulyte J, Lo Torto F, et al. “To Pre or Not to Pre”: introduction of a prepectoral breast reconstruction assessment score to help surgeons solving the decision-making dilemma retrospective results of multicenter experience. Plast Reconstr Surg. 2021;147(6):1278–86.

    Article  CAS  PubMed  Google Scholar 

  56. Neville A, Lee L, Antonescu I, et al. Systematic review of outcomes used to evaluate enhanced recovery after surgery. Br J Surg. 2014;101(3):159–70.

    Article  CAS  PubMed  Google Scholar 

  57. Fiore JF Jr, Faragher IG, Bialocerkowski A, Browning L, Denehy L. Time to readiness for discharge is a valid and reliable measure of short-term recovery after colorectal surgery. World J Surg. 2013;37:2917–34.

    Article  Google Scholar 

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Acknowledgment

The authors thank Mena Jalali and Sharon Grutman for their administrative efforts on this project and the Executive Board of the American Society of Breast Surgeons for its support of this workgroup. They also thank Sara Fluharty (perioperative nursing representative) and Eileen Fuentes (patient advocate) for their participation in this project.

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Correspondence to Kandice Ludwig MD.

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Ludwig, K., Wexelman, B., Chen, S. et al. Home Recovery After Mastectomy: Review of Literature and Strategies for Implementation American Society of Breast Surgeons Working Group. Ann Surg Oncol 29, 5799–5808 (2022). https://doi.org/10.1245/s10434-022-11799-4

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