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A pilot study of a breast surgery Enhanced Recovery After Surgery (ERAS) protocol to eliminate narcotic prescription at discharge

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Abstract

Background

The evolving conceptualization of the management of surgical pain was a major contributor to the supply of narcotics that led to the opioid crisis. We designed and implemented a breast surgery-specific Enhanced Recovery After Surgery (ERAS) protocol using opioid-sparing techniques to eliminate narcotic prescription at discharge without sacrificing perioperative pain control.

Methods

A pilot observational study included patients with and without cancer undergoing lumpectomy. The convenience sample consisted of an ERAS group and a control usual care (UC) group who underwent surgery during the same time period. Discharge narcotic prescriptions were compared after converting to oral morphine milligram equivalents (MME’s). Postoperative day one and week one pain scores were also compared between the two groups.

Results

Ninety ERAS and 67 UC patients were enrolled. Most lumpectomies were wire-localized, and half of the patients in each group had breast cancer. There were more obese patients in the ERAS group. UC lumpectomy patients were discharged with a median of 54.5 MMEs (range 0–120), while the ERAS lumpectomy patients were discharged with none (p < 0.001). Postoperative pain scores were not significantly different between groups, and there were few complications.

Conclusion

A breast surgery-specific ERAS protocol employing opioid-sparing techniques successfully eliminated postoperative narcotic prescription without sacrificing perioperative pain control or increasing postoperative complications. By promoting the adoption of similar protocols, surgeons can continue to improve patient outcomes while decreasing the quantity of narcotics available for diversion within our patients’ communities.

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References

  1. Ljungqvist O, Scott M, Fearon KC (2017) Enhanced recovery after surgery: a review. JAMA Surg 152(3):292–298

    Article  PubMed  Google Scholar 

  2. Batdorf NJ, Lemaine V, Lovely JK et al (2015) Enhanced recovery after surgery in microvascular breast reconstruction. J Plast Reconstr Aesthet Surg 68(3):395–402

    Article  PubMed  Google Scholar 

  3. ClinCalc.com (2018). Evidence-based clinical decision support tools and calculators for medical professionals: equivalent opioid calculator. http://www.Clincalc.com/opioids/. Accessed Mar 1 2018

  4. U.S. Department of Health and Human Services (2018). About the U.S. opioid epidemic: the opioid epidemic by the numbers. http://www.HHS.gov/opioids. Accessed Mar 1 2018

  5. Sullivan A. The opioid epidemic is this generation’s AIDS crisis. New York Magazine. March 16, 2017. http://nymag.com/daily/intelligencer/2017/03/the-opioid-epidemic-is-this-generations-aids-crisis.html. Accessed Apr 1 2018

  6. Center for Disease Control (1995). First 500,000 AIDS Cases- United States, 1995. MMWR Weekly 44(46):849–853

    Google Scholar 

  7. World Health Organization (2003). World Health Report HIV/AIDS: Confronting a Killer. http://www.who.int/whr/2003/en/Chapter3.pdf. Accessed Apr 4 2018

  8. Volkow N, McLellan T (2016) Opioid abuse in chronic pain-misconceptions and mitigation strategies. NEJM 374:1253–1263

    Article  PubMed  CAS  Google Scholar 

  9. Jones C, Paulozzi L, Mack K (2014) Research Letter: Sources of prescription opioid pain relievers by frequency of past-year nonmedical use United States, 2008–2011. Jama Int Med 174(5):802–803

    Article  Google Scholar 

  10. Shei A, Rice JB, Kirson NY, Bodnar K, Bimbaum HG, Holly P, Ben-Joseph R (2015) Sources of prescription opioids among diagnosed opioid abusers. Curr Med Res Opin 31:779–784

    Article  PubMed  CAS  Google Scholar 

  11. Liang X, Liu R, Chen C, Fang J, Tianzuo L (2016) Opioid system modulates the immune function: a review. Transl Perioper Pain Med 1(1):5–13

    PubMed  PubMed Central  Google Scholar 

  12. Afsharimani B, Cabot P, Parat M (2011) Morphine and tumor growth metastasis. Cancer Metastasis Rev 30(2):225 – 38

    Article  PubMed  CAS  Google Scholar 

  13. Toms L, McQuay HJ, Derry S, Moore RA (2008) Single dose oral paracetamol (acetaminophen) for postoperative pain in adults. Cochrane Database of Systematic Reviews 2008, Issue 4. Art. No.: CD004602

  14. Derry CJ, Derry S, Moore RA (2013) Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010210

  15. Sharma S, Chang D, Koutz C, Evans GR, Robb GL, Langstein HN, Kroll SS (2001) Incidence of hematoma associated with ketorolac after TRAM flap breast reconstruction. Plast Reconstr Surg 107(2):352–355

    Article  PubMed  CAS  Google Scholar 

  16. Motov S, Yasavolian M, Likourezos A et al (2017) Comparison of intravenous ketorolac at three single-dose regimens for treating acute pain in the emergency department: a randomized controlled trial. Ann Emerg Med 70(2):178–194

    Article  Google Scholar 

  17. Duttchen K, Lo A, Walker A, McLuckie D, De Guzman C, Roman-Smith H, Davis M (2017) Intraoperative ketorolac dose of 15 mg versus the standard 30 mg on early postoperative pain after spine surgery: a randomized, blinded, non-inferiority trial. J Clin Anesth 41:11–15

    Article  PubMed  CAS  Google Scholar 

  18. Wide-ranging online data for epidemiologic research (WONDER) (2018) Centers for Disease Control and Prevention Website National Center for Health Statistics. http://wonder.cdc.gov. Updated February 9, 2018. Accessed Apr 1 2018

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Acknowledgements

We would like to thank the Maimonides Medical Center Anesthesiologists and Perioperative Staff, General Surgery and Anesthesiology Residents, Pharmacy Staff, and the Staff of the Brooklyn Breast Center of Maimonides Medical Center. Special thanks to Johanna Yu BSN, RN, Mohamad Hashim MD, Nermin Ahmed-Yakop, Carin Zelkowitz PA-C, Jeffey Jacobs PA-C, Mary-Ann Myrthil PA-C, and Fara Maldonado whose cooperation and flexibility in implementing and promoting the ERAS protocol was not only beneficial to our study but to our patients.

Funding

This study did not receive funding.

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Correspondence to Kristin E. Rojas.

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All authors declare that they have no conflicts of interest.

Human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Additional information

The authors report no commercial interests relevant to the present work. There was no outside source of financial or material support for this study.

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Rojas, K.E., Manasseh, DM., Flom, P.L. et al. A pilot study of a breast surgery Enhanced Recovery After Surgery (ERAS) protocol to eliminate narcotic prescription at discharge. Breast Cancer Res Treat 171, 621–626 (2018). https://doi.org/10.1007/s10549-018-4859-y

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  • DOI: https://doi.org/10.1007/s10549-018-4859-y

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