Skip to main content

Advertisement

SpringerLink
Log in

Venous Thromboembolism Following Abdominal Cancer Surgery in the Korean Population: Incidence and Validation of a Risk Assessment Model

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

A cancer patient slated for abdominal surgery is considered to be at moderate to high risk for developing venous thromboembolism (VTE), but the incidence is quite low in Korean patients. Most risk assessment models and recommendations for VTE management are from Western reports, however they possibly overestimate the risk of VTE in the Korean population.

Methods

We retrospectively reviewed the medical records of 1966 patients who were diagnosed with abdominal organ cancer and required surgical treatment.

Results

Each patient was rated using the Caprini risk scoring model. The mean score was 7.5 ± 0.7 points; 98.4% of patients were classified as high risk for VTE. Symptomatic VTE occurred in eight patients, and the overall incidence was 0.4%. The mean Caprini score for VTE patients was 8.8 ± 1.9 points. In the group with scores between 5 and 9 points, the incidence was 0.3–0.5%, while in patients with scores > 10 points, the incidence of VTE was found to be 1.12%.

Conclusions

The risk stratification system in the Caprini scoring model needs to be modified based on the actual incidence in the Korean population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. De Cicco M. The prothrombotic state in cancer: pathogenic mechanisms. Crit Rev Oncol Hematol. 2004;50:187–96.

    Article  PubMed  Google Scholar 

  2. Fuentes HE, Tafur AJ, Caprini JA. Cancer-associated thrombosis. Dis Mon. 2016;62:121–58.

    Article  PubMed  Google Scholar 

  3. Falanga A, Marchetti M, Vignoli A. Coagulation and cancer: biologic and clinical aspects. J Thromb Haemost. 2013;11:223–33.

    Article  CAS  PubMed  Google Scholar 

  4. Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon. 2005;51:70–8.

    Article  PubMed  Google Scholar 

  5. Bahl V, Hu HM, Henke PK, et al. A validation study of a retrospective venous thromboembolism risk scoring method. Ann Surg. 2010;251:344–50.

    Article  PubMed  Google Scholar 

  6. Zhou HX, Peng LQ, Yan Y, et al. Validation of the caprini risk assessment model in Chinese hospitalized patients with venous thromboembolism. Thromb Res. 2012;130:735–40.

    Article  CAS  PubMed  Google Scholar 

  7. Zhou H, Wang L, Wu X, et al. Validation of a venous thromboembolism risk assessment model in hospitalized chinese patients: a case-control study. J Atheroscler Thromb. 2014;21:261–72.

    Article  PubMed  Google Scholar 

  8. Liew NC, Alemany GV, Angchaisuksiri P, et al. Asian venous thromboembolism guidelines: updated recommendations for the prevention of venous thromboembolism. Int Angiol. 2017;36:1–20.

    PubMed  Google Scholar 

  9. Lee LH, Gallus A, Jindal R, et al. Incidence of venous thromboembolism in Asian populations: a systematic review. Thromb Haemost. 2017;117:2243–60.

    Article  PubMed  Google Scholar 

  10. Jang MJ, Bang SM, Oh D. Incidence of venous thromboembolism in Korea: from the Health Insurance Review and Assessment Service database. J Thromb Haemost. 2011;9:85–91.

    Article  CAS  PubMed  Google Scholar 

  11. Yhim HY, Jang MJ, Bang SM, et al. Incidence of venous thromboembolism following major surgery in Korea: from the Health Insurance Review and Assessment Service database. J Thromb Haemost. 2014;12:1035–43.

    Article  PubMed  Google Scholar 

  12. Yu YB, Gau JP, Liu CY, et al. A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system. Thromb Haemost. 2012;108:225–35.

    Article  CAS  PubMed  Google Scholar 

  13. Hong J, Lee JH, Yhim HY, et al. Incidence of venous thromboembolism in Korea from 2009 to 2013. PLoS ONE. 2018;13:e0191897.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Law Y, Chan YC, Cheng SWK. Epidemiological updates of venous thromboembolism in a Chinese population. Asian J Surg. 2018;41:176–82.

    Article  PubMed  Google Scholar 

  15. Chew HK, Wun T, Harvey D, et al. Incidence of venous thromboembolism and its effect on survival among patients with common cancers. Arch Intern Med. 2006;166:458–64.

    Article  PubMed  Google Scholar 

  16. Hammond J, Kozma C, Hart JC, et al. Rates of venous thromboembolism among patients with major surgery for cancer. Ann Surg Oncol. 2011;18:3240–7.

    Article  PubMed  Google Scholar 

  17. Heit JA. The epidemiology of venous thromboembolism in the community: implications for prevention and management. J Thromb Thrombolysis. 2006;21:23–9.

    Article  PubMed  Google Scholar 

  18. Horsted F, West J, Grainge MJ. Risk of venous thromboembolism in patients with cancer: a systematic review and meta-analysis. PLoS Med. 2012;9:e1001275.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Naess IA, Christiansen SC, Romundstad P, et al. Incidence and mortality of venous thrombosis: a population-based study. J Thromb Haemost. 2007;5:692–9.

    Article  CAS  PubMed  Google Scholar 

  20. White RH, Keenan CR. Effects of race and ethnicity on the incidence of venous thromboembolism. Thromb Res. 2009;123 Suppl 4:S11–7.

    Article  CAS  PubMed  Google Scholar 

  21. Parikh KC, Oh D, Sittipunt C, et al. Venous thromboembolism prophylaxis in medical ICU patients in Asia (VOICE Asia): a multicenter, observational, cross-sectional study. Thromb Res. 2012;129:e152–8.

    Article  CAS  PubMed  Google Scholar 

  22. Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141:e227S–e77S.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Klatsky AL, Amstrong MA, Poggi J. Risk of pulmonary embolism and or deep venous thrombosis in Asian-Americans. Am J Cardiol. 2000;85:1334–7.

    Article  CAS  PubMed  Google Scholar 

  24. Ridker PM, Miletich JP, Hnnekens CH, et al. Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening. JAMA. 1997;277:1305–7.

    CAS  PubMed  Google Scholar 

  25. Lyman GH, Bohlke K, Khorana AA, et al. Venous thromboembolism prophylaxis and treatment in patients with cancer: American Society of Clinical Oncology clinical practice guideline update 2014. J Clin Oncol. 2015;33:654–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Streiff MB, Holmstrom B, Ashrani A, et al. Cancer-associated venous thromboembolic disease, version 1.2015. J Natl Compr Canc Netw. 2015;13:1079–95.

Download references

Acknowledgment

The authors thank Kyung-Hye Kwon for assistance with the data collection.

Funding

None.

Author information

Authors and Affiliations

  1. Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea

    Mi-hyeong Kim MD, PhD, Kang-woong Jun MD, Jeong-kye Hwang MD, PhD, Sang-dong Kim MD, PhD, Jang-yong Kim MD, PhD, Sun-cheol Park MD, PhD, Yong-sung Won MD, PhD, Sang-seop Yun MD, PhD & In-sung Moon MD, PhD

  2. Division of Vascular and Transplant Surgery, Department of Surgery, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu-si, Gyeonggi-do, Korea

    Ji-il Kim MD, PhD

Authors
  1. Mi-hyeong Kim MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kang-woong Jun MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jeong-kye Hwang MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sang-dong Kim MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jang-yong Kim MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sun-cheol Park MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yong-sung Won MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sang-seop Yun MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. In-sung Moon MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ji-il Kim MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ji-il Kim MD, PhD.

Ethics declarations

Disclosure

Mi-hyeong Kim, Kang-woong Jun, Jeong-kye Hwang, Sang-dong Kim, Jang-yong Kim, Sun-cheol Park, Yong-sung Won, Sang-seop Yun, In-sung Moon, and Ji-il Kim have no conflicts of interest to declare.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, Mh., Jun, Kw., Hwang, Jk. et al. Venous Thromboembolism Following Abdominal Cancer Surgery in the Korean Population: Incidence and Validation of a Risk Assessment Model. Ann Surg Oncol 26, 4037–4044 (2019). https://doi.org/10.1245/s10434-019-07633-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1245/s10434-019-07633-z

Search

Navigation