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Impact of ypT, ypN, and Adjuvant Therapy on Survival in Gastric Cancer Patients Treated with Perioperative Chemotherapy and Radical Surgery

  • Gastrointestinal Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Perioperative chemotherapy and surgery is the standard of care in advanced gastroesophageal cancer patients, but its impact among those treated with radical surgery still needs further assessment. We present the results of this multimodality treatment approach in a gastric cancer patients cohort treated with D2 lymphadenectomy. We aimed to identify prognostic factors associated with improved survival.

Patients and Methods

This retrospective cohort study enrolled patients treated with perioperative chemotherapy and resection in a single cancer center in Brazil between 2006 and 2016. Subjects presenting tumors of the gastric stump, esophageal tumors, or treated with intraperitoneal chemotherapy were excluded. Intention-to-treat survival analysis was performed for all subjects who started neoadjuvant chemotherapy, and prognostic factors were determined among those who had R0 resection.

Results

This study included 239 patients, of whom 198 had R0 resection. The mean age was 59.9 years, and most had clinical stage IIB or III disease (88%). Among the 239 patients who started neoadjuvant chemotherapy, 207 (86.6%) completed all neoadjuvant treatment cycles, and surgical resection was performed in 225 subjects (94.1%). Overall 60-day morbidity and mortality rates were 35.6% and 4.4%, respectively. For the entire cohort, median survival was 78 months and the 5-year survival rate was 55.3%. Factors associated with worse survival were ypT3–4 stage, ypN + stage, extended resection, and no adjuvant chemotherapy.

Conclusions

Perioperative chemotherapy resulted in very good outcomes for patients treated with radical surgery, and downstaging after chemotherapy was shown to be a major determinant of prognosis.

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Acknowledgment

The authors acknowledge the financial support given by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Project 2014/26897-0.

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Authors and Affiliations

  1. Department of Abdominal Surgery, A. C. Camargo Cancer Center, Sao Paulo, Brazil

    Felipe José Fernández Coimbra MD, Héber S. C. Ribeiro MD, Alessandro L. Diniz MD, André Luís de Godoy MD, Igor Correia de Farias MD & Wilson L. da Costa Jr. MD, PhD

  2. Department of Clinical Oncology, A. C. Camargo Cancer Center, São Paulo, Brazil

    Victor Hugo F. de Jesus MD, Tiago Felismino MD, Celso A. L. Mello MD, PhD & Rachel S. P. Riechelmann MD, PhD

  3. Department of Radiology, A. C. Camargo Cancer Center, São Paulo, Brazil

    Maria Fernanda Almeida MD

  4. Department of Surgical Pathology, Hospital Sírio-Libanês, São Paulo, Brazil

    Maria Dirlei F. S. Begnami MD, PhD

  5. Laboratory of Medical Genomics, A. C. Camargo Cancer Center, São Paulo, Brazil

    Emmanuel Dias-Neto PhD

Authors
  1. Felipe José Fernández Coimbra MD
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  2. Victor Hugo F. de Jesus MD
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  9. Maria Fernanda Almeida MD
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  13. Wilson L. da Costa Jr. MD, PhD
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Corresponding authors

Correspondence to Felipe José Fernández Coimbra MD or Wilson L. da Costa Jr. MD, PhD.

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Coimbra, F.J.F., de Jesus, V.H.F., Ribeiro, H.S.C. et al. Impact of ypT, ypN, and Adjuvant Therapy on Survival in Gastric Cancer Patients Treated with Perioperative Chemotherapy and Radical Surgery. Ann Surg Oncol 26, 3618–3626 (2019). https://doi.org/10.1245/s10434-019-07454-0

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  • DOI: https://doi.org/10.1245/s10434-019-07454-0

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