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Salvage Esophagectomy After Definitive Chemoradiotherapy for Patients with Esophageal Squamous Cell Carcinoma: Who Really Benefits from this High-Risk Surgery?

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to identify good candidates for salvage esophagectomy after definitive chemoradiotherapy (dCRT), based on safety and survival.

Methods

Sixty-three patients who underwent salvage esophagectomy, after dCRT, at the Cancer Institute Hospital, Tokyo, Japan, between 1988 and 2013, were retrospectively analyzed. Short-term outcomes were evaluated by reviewing postoperative complications, length of postoperative hospital stay, and mortality. Survival rates were calculated using the Kaplan–Meier method, and statistical significance was determined using the log-rank test. The Cox proportional hazards model was used for univariate and multivariate analyses of overall survival. Univariate logistic regression analysis was used to identify factors related to R0 resection.

Results

Postoperative complications occurred in 41 patients (65.1 %), and the mortality rate was 7.9 %. In-hospital deaths did not occur among patients with less advanced tumors prior to dCRT (cT1–2 and cN0), or among those who had previously achieved a complete response (CR); the 3- and 5-year overall survival rates were 29.8 % and 15.0 %, respectively. Univariate analysis revealed that residual disease, tumor depth, dCRT response, lymph node metastasis, and time to relapse were significant factors affecting overall survival. Multivariate analysis demonstrated that R0 resection and ypT0–2 tumors were significant, favorable prognostic factors in patients undergoing salvage esophagectomy. In addition, cT1–2 tumors, initially resectable tumors, ycT1–2 tumors, and relapse after CR were factors predicting R0 resection.

Conclusions

Based on both short- and long-term outcomes, patients with pretreatment or preoperative T1–2 tumors and those with relapse after CR are good candidates for salvage esophagectomy.

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Disclosure

Masayuki Watanabe, Shinji Mine, Koujiro Nishida, Kazuhiko Yamada, Hironobu Shigaki, Akira Matsumoto, and Takeshi Sano have no disclosure to declare.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan

    Masayuki Watanabe MD, PhD, FACS, Shinji Mine MD, Koujiro Nishida MD, PhD, Kazuhiko Yamada MD, PhD, Hironobu Shigaki MD, PhD, Akira Matsumoto MD & Takeshi Sano MD, PhD

Authors
  1. Masayuki Watanabe MD, PhD, FACS
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  2. Shinji Mine MD
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  3. Koujiro Nishida MD, PhD
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  4. Kazuhiko Yamada MD, PhD
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  5. Hironobu Shigaki MD, PhD
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  6. Akira Matsumoto MD
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  7. Takeshi Sano MD, PhD
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Corresponding author

Correspondence to Masayuki Watanabe MD, PhD, FACS.

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Watanabe, M., Mine, S., Nishida, K. et al. Salvage Esophagectomy After Definitive Chemoradiotherapy for Patients with Esophageal Squamous Cell Carcinoma: Who Really Benefits from this High-Risk Surgery?. Ann Surg Oncol 22, 4438–4444 (2015). https://doi.org/10.1245/s10434-015-4556-6

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  • DOI: https://doi.org/10.1245/s10434-015-4556-6

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