Background

Traditional knowledge of plants has always been transferred from generation to generation throughout the natural course of everyday life [1]. This important knowledge, collated through ethnobotanical studies, is valuable for conservation, and establishment of the local and indigenous plant usages has significant benefits [2]. Turkey has an enormous potential for the exploration of new ethnobotanical usages because of its extremely rich plant diversity [3]. The Turkish flora comprises more than 11,700 plant taxa (about 30% of these are endemic taxa) [4], and the Turkish people have a broad knowledge of folkloric medicines; therefore, Turkey represents a huge resource for ethnobotanical usage studies [5]. Plants are commonly used by Turkish people for traditional remedies, as an herbal tea, food, spice, firewood, dye, furniture, agricultural tools, construction materials, and indoor plants [4]. Many ethnobotanical studies include general medical usage, but these studies are fewer in number than those about non-medical ethnobotanical usages [6].

Recently, botanists in Turkey have started using a different approach in ethnobotanical studies. When they conduct a floristic study in a specific area, an ethnobotanical survey study section is added [7]. Previous studies in Turkey have included a section of ethnobotanical usages at the end of the flora section.

Ethnobotanical studies have been on the increase in many regions of Turkey [1, 8,9,10,11,12,13]. In Midyat (Mardin Province, Turkey), people benefit from the diversity of flora by using plants as a rich source of medicine. Medicinal plants were used by Anatolian cultures, hence the accumulation of large amounts of remarkable medicinal folk knowledge in the region [14]. Although there are some studies in eastern Anatolia [15, 16], the southeast region of Anatolia is still a poor area in terms of ethnobotany studies. Midyat has a great diversity of plant species given its climatic variation and different ecological habitats. The different ways of life and rich culture in the districts of Midyat have created diverse ethnobotanical usages. One of the oldest traditional plant usages is medicinal, which depends on knowledge and practical experience of using these natural materials. As far as the authors know, this is the first ethnobotanical study conducted in Midyat, Turkey. The primary objective of this study was to identify and document the medicinal ethnobotanical plants and associated ethnobotanical knowledge of the local people. The secondary purpose was to uncover new ethnobotanical usages such as endemic and endangered plant usages, and to evaluate the plant usages in the different ethnic groups in the region.

Methods

Study area

This study was conducted in Midyat, located at 37°25′ N – 41°22′ E, in south-eastern Turkey (Fig. 1). The district is located in the south-eastern part of Anatolia. Midyat covers an area of 1394 km2 and is located at 1070 m above sea level. The region is rugged and not surrounded by high mountains [17]. The population is 105,952 (2015). In Midyat, there is not only a mixture of cultures, but also a mixture of religions: Syriacs (Christian), Yexidians and Muslims have lived together for thousands of years. Four different languages, Turkish, Arabic, Syriac, and Kurdish, are spoken in this region. For example, in Eglence, a village in the region, people speak Arabic and Kurdish in their daily life. In a Christian village, Haberli, local people speak Arabic, Syriac, and Kurdish. Additionally, in all locations Turkish is the official language; therefore, all young generations speak Turkish very well.

Fig. 1
figure 1

Map of Midyat and districts. Provinces: 1-Doruk, 2-Tasci, 3-Sarikaya, 4-Tepecik, 5-Kayapinar, 6-Ziyaret, 7-Alicli, 8-Harmanli, 9-Camyurt, 10-Dogancay, 11-Yenice, 12-Baglarbasi, 13-Narli, 14-Baristepe, 15-Gulveren, 16-Yolbasi, 17-Pelitli, 18-Yemisli, 19-Sivrice, 20-Budakli, 21-Icoren, 22-Turgali, 23-Eglence, 24-Tepeli, 25-Yayvantepe, 26-Altintepe, 27-Senkoy, 28-Acirli, 29-Haberli

Socio-economic profile

In Midyat, agriculture, husbandry, and handcrafts are the most important sources of income for the region’s economy. 66.8% of income in the area is from husbandry and agriculture [18]. Traditional hand-made silver products and hand-crafted stonework, fabric painting, and jewelry-making are still important [17]. The most important crops are wheat and barley, followed by cotton, pistachio, olives, grapes, apples, pears, plums, and walnuts [18].

Ethnographic background

Midyat, formerly known as Matiat, was built in the ninth century BCE by Syriac settlers, and a record of it was found written on Assyrian tablets [17]. The Silk Road is an historic route for overland travelers. The town of Mardin in south-eastern Turkey is an attraction of the Silk Road [19]. The Silk Road is more than just a trade route linking Asia and Europe; it is a display of cultures, ethnicities and religions that have settled in the region, and presents 2000 years of historical and cultural wealth [20]. From east to west, it was used in transporting silk, porcelain, paper, spices, and jewels for cultural exchange between continents [19].

During the Middle Ages, the Silk Road extended along multiple routes from Asia to Anatolia and from Thrace to Europe [21]. The Silk Road in the south of Anatolia passes by Mardin, Adıyaman, Kayseri, Konya, Denizli, and Antalya [19]. Mardin was also an important stopover point along the Silk Road due to its strategic position at the junction of two transit roads [17]. Before the Ottoman empire in the eleventh century, the Seljuk empire – a medieval Turko-Persian-Sunni Muslim empire – provided security by building caravanserais on these roads: there are five inns and caravanserais in Midyat in order to keep the commercial activities in Anatolia alive [19].

Climate and topography

Midyat is one of the most important floristic regions in south-eastern Turkey. The studied area has a potential to reflect the endemic characteristics of the Irano-Turanian flora and some xeric Indo-Malaysia forms. Summer is very hot, at an average of around 35 °C in June, and winter is cold, with an average temperature of 0.5 °C in January [22].

The study was carried out from 2007–2010, March through late December, when plants were in flowering and fruiting periods. The information on the local names of plants, their usage and preparation were obtained from local citizens (123 respondents) through individual interviews. Most respondents were also asked about the source of their knowledge in order to eliminate information of secondary nature. This information was checked with that from other areas and neighboring villages in order to verify its accuracy. The plants were collected with the help of respondents. In the study area, different religions, languages, and ethnicities are present, which presented us with the advantage of being able to find new and preserved ethnobotanical knowledge from different cultures.

Ethnobotanical data collection

This study was conducted in Midyat to evaluate the usage of the natural plant flora. Information was gathered by interviewing 123 local people from 30 districts in Midyat and surrounding areas. People showed us plants from the field or dried samples from their properties for our records.

Identification of the specimens from our field collections revealed 92 taxa belonging to 32 plant families. These specimens were identified using the “Flora of Turkey” [23]; we compared them with the specimens in the Herbarium of Ege University, Izmir, Turkey, and listed the names of plant families in alphabetic order. The voucher specimens were also deposited in the Herbarium of Ege University. Plants were identified according to the International Plant Name Index (IPNI: http://www.theplantlist.org/). Plant usages were examined by focusing on natural plant usages, not only on agricultural usages.

Ethno usages of the plants are given under their taxa names with voucher specimen numbers, in alphabetical order. In respective columns, the family, local name, preparation method, and used parts of the plants are recorded. The last column shows literature reports with references (Table 1).

Table 1 Ethnobotanical usages of the plants in the study area

Interviews with local people

Information was collected from locals by free-listed observations and semi-structured interviews of people in public areas (generally in fields, tea houses, mosques, churches, village squares, etc.). Local people talked about the collected plants in the fields; the people of Midyat are extremely generous in helping others whom they know. Especially in Midyat, we tried to obtain information from the oldest local people; however, several issues overshadowed data collection. First, people were scared of the threat of terror, which made it difficult to obtain any information. Second, communication sometimes caused problems because of the different languages that people speak in the region. This study was conducted in Turkish, but in order to reach all different groups, assistance was needed. We could only work with local people who spoke the local languages and who were familiar with the people in the area. By using local guidance, we conducted our interviews with local people without much difficulty. Since one of the authors has relations in the area, we got guidance from 15–20 locals with different backgrounds that spoke the same language as local people. We also used guidance to reach more people who have other ethnic or faith backgrounds, such as Syriac Christians. Similarly, teachers, imams (ministers) of mosques and churches, headmen of the villages, and the members of the security services of the villages assisted us in obtaining information from local people. The International Society of Ethnobiology Code of Ethics was taken into account in interviews [24].

Demographic characteristics of study participants

We conducted face-to-face interviews and surveyed a variety of different participants. We identified and recorded demographic characteristics. We interviewed 123 persons, of which more than 70% were older than 55 years; the mean respondent age was 64 (Table 2). 66% of the participants were male, while female participants made up 34% of the survey.

Table 2 Demographic details of the interviewed informants

The demographical characteristics of individuals are illustrated in Table 2. During the interviews, we consulted at least one person who could speak the local language and had a connection with local people. Since the research area was not a secure region, we also had permission from local police officers.

Quantitative method for analysis

We conducted our study by use value method [25], a quantitative method that demonstrates the relative importance of locally known taxa. It was calculated according to the following formula: Use value (UV), a quantitative method that demonstrates the relative importance of plant species known locally, was also evaluated according to the following formula [26]:

$$ \mathrm{UVi}=\sum \mathrm{Ui}/\mathrm{Ni} $$

where UVi refers to the use value of a species, Ui to the number of citations per specific plant species, and Ni to the number of informants. A high UV indicates the potential importance of the plant species reported.

Results and discussion

The focus of the study was to identify wild plants, instead of agricultural plants, with medicinal usages. This study will fill a gap in the knowledge about different usages of endemic and rare plants. In this study, Midyat was selected because of the mixed cultures and the fact that no ethnobotanical or floristic studies had been conducted in this region. We focus on: 1) identifying medicinal plant usages 2) determining new ethnobotanical usages and evaluating our findings in terms of cultural ethnobotany.

In the course of this study, we collected 368 voucher specimens in the investigated area. According to identification results, 92 were traditional plants (81 wild taxa and 11 cultivated plant taxa) (Table 1). Most respondents stated that they had learned the ethnobotanical uses of plants from their parents and elderly relatives. Wild-growing plants were not considered as holding the same economic value as cultivated plants in the studied area. Among the 92 taxa of traditional plants (129 plant usages), 35% were used for medical purposes, 22% for food, 13% for animal fodder, 7% as ornaments and dyes, 6% for broom production, 4% for latex and as fragrance, 4% for herbal tea, molasses and wine preparation, 3% for agricultural purposes, and 6% were used for different purposes (Fig. 2). Within the observed taxa, 21 new ethnobotanical usages were determined in this study.

Fig. 2
figure 2

The percentage of ethnobotanical usages in Midyat

Local people use various parts of the plants in the region. Of the 92 identified plant taxa, 49% are used for their aerial parts, 20% for their fruits, 9% for their flowers, and 15% for their leaves, stem and roots; in 7%, other parts are used. We compared our findings with previous ethnobotanical studies in Turkey and other countries (Table 1). Our study indicates the importance to document not only medicinal plants, but also edible plants or plants used for fodder, fuel, dyes, and other purposes. In our study, specific and interesting plant usages were determined, such as using the whole of an endemic plant as a broom, herbal tea against cold, or painting Easter eggs with plant dyes. The conservation of this extensive knowledge is crucial, particularly because knowledge is no longer being passed down from older to younger generations.

Highly utilized species

Use value (UV) is a very important tool for demonstrating the relative importance of medicinal plants in the designated area. Based on our analyses, UV ranges from 0.10 to 0.20 reveal the common ethnobotanical usages for the following taxa: Anthemis cotula (0.12), Allium cepa (0.13), Alcea striata subsp. striata (0.14), Crupina crupinastrum (0.12), Papaver rhoeas (0.13), Salvia multicaulis (0.14), Thymbra spicata (0.11), and Vicia pannonica subsp. striata (0.15). The highest UVs are recorded for Teucrium polium (0.51), Matricaria aurea (0.26), Alcea setosa (0.21), and Malva neglecta (0.21) (Fig. 3, Table 3).

Fig. 3
figure 3

Most common plant usages in Midyat

Table 3 A Important plant usages with preparation and application methods in Midyat 724. B Endemic plants usages in Midyat

Especially in villages of Midyat, people can easily find highly utilized species. The villagers always keep a dried flowers and plant materials for medical usages or food additives. As an example, Teucrium polium, Matricaria aurea, and Alcea setosa are always presents in many houses in Midyat. Especially, Teucrium polium is a well-known remedy in the region, and the dried plant can be found also in local sellers in the city center. Moreover, several other ethnobotanical usages such as soups, ornaments, and fresh plants can be found in local stores in Midyat. Most of plant species that have high UVs can be grown easily such as Matricaria aurea, Alcea setosa, and Malva neglecta. Animal fodders are also common usages in the region because they have grown easily and collected by several villagers in Midyat.

Some highly utilized plant species have already been investigated in terms of biological and chemical properties. For example, Teucrium polium has a wide range of applications in the region; owing to unique phytochemicals with new biological activities, more than 130 compounds have been identified so far, and it is used as an anti-inflammatory, antinociceptive, antispasmodic, anticancer, antimutagenic, hypoglycemic, hypolipidemic, hypotensive, anti-ulcer, and antimicrobial [27]. In our study, aerial parts of Teucrium polium are used mainly against stomachaches and stomach pains in humans and also animals. Other reported uses of this species are to combat diabetes, diarrhea, and rheumatoid arthritis in Gaziantep [28]; for digestion in Egypt; as food in Albania and Algeria [29]; for liver diseases in Iran [30]; for diabetes and kidney issues in Jordan [31]; and for diarrhea and hemorrhoids in eastern Turkey [32]. Interestingly, the authors were warned that extended use of Teucrium polium could cause adverse effects in the liver and kidney [27]. In our study area, there is a very intense usage of Teucrium polium, and local people need to be aware of the potential adverse effects of these usages.

Matricaria aurea’s essential oils are very rich in chemical compounds, such as phenolic coumarin, which contribute to a moderate antioxidant and antibacterial activity [33]. Matricaria aurea has seven different usages: for cough, flu, bronchial complaints, stomachache, cardialgia, as a soda, food, and fragrance. It is mainly used to treat stomachaches and colds by consuming it as an herbal tea. It was reported in previous studies carried out in Jordan that it is used to treat throat and back pains and high blood pressure in children, as a sedative, and an anti-inflammatory substance [31]. Alcea setosa (UV 0.21) is traditionally used as a pain reliever, a healing agent, and to treat coughs. Alcea setosa is reported for anti-inflammatory treatment of asthma in Jordan with UV 0.11 [31], and the leaves of plant are expectorative and diuretic [14]. The flowers and fruits of Alcea striata subsp. striata are used as hair dye and in beauty products in Midyat. The same taxon is also used to heal respiratory system disease in Şanlıurfa with a similarly high UV 0.12 [15]. Malva neglecta has UV 0.21, and six different usages are reported in Midyat. It is used as a food, against stomachache, for children’s toys, in order to lose weight, against labor pain, kidney diseases, as a diuretic, and to make traditional rolling leaves with rice, called sarma. Several studies reported its use as food [15, 34] and as skin ointment [15, 32]. Malva neglecta is used to heal kidney diseases, and in another study from eastern Turkey, the use of this plant to treat abscesses was also reported [35].

In the current study, Anthemis cotula is used for several purposes, such as for treating colds by brewing it as an herbal tea, against bronchitis, as a hair treatment, and as a treatment for flu and stomachaches in Midyat. Some similar usages of Anthemis cotula are reported for treating colds, hair loss and bronchitis [1, 36]. Salvia multicaulis has an interesting usage in the region: as an antidote against scorpion bites (Table 3). Salvia multicaulis is also used as an herbal tea in Midyat, Cizre, and in Elazığ [16, 37, 38], and as a spice and to heal skin wounds in the southeast of Turkey [16, 39].

Previously we discussed the ethnobotanical usages with the highest UV value in Midyat. Some less common but no less interesting usages were also reported: Thymbra spicata is used in Midyat as an herbal tea for stomachaches. In addition, it is used as an antiseptic [35], as a spice [28], and the leaves of plant are also used in the process of making cheese [37] in southeast regions of Turkey. Capparis spinosa is used for diabetes treatment and as an ingredient in pickle. It is used as a pickle, food, and fodder in Şanlıurfa [15, 16], and as a pain reliever and to treat rheumatoid arthritis in Jordan [40]. Lepidium draba is consumed as a food in Midyat. In Elazığ province, the fruits of this plant are used as a spice [40], and it is eaten fresh in Iran [30]. Fruits of Prunus mahaleb are consumed as a food and against coughing. It is used as a food in Agri [41], and the seeds of plant are used as an expectorative, diuretic substance, and to treat inflammation in Elazığ [38]. Centaurea kurdica is boiled in water and used for healing kidney disease. Moreover, the flowers are used as a sedative in Elazığ [38]. Chondrilla juncea is used as a gum in Elazığ [38], as a broom [42] and against stomachaches in eastern parts of Turkey [42]. Eryngium campestre are peeled and eaten in Midyat (Fig. 4). It is also used to treat intestinal disorders [28], flatulence, hepatitis [41], digestion disorders, and muscle pain [29]. Eryngium campestre is consumed as a food in neighboring cities such as Cizre [16]. An unusual ethnobotanical finding was uncovered that children suck the flowers of Ixiolirion tataricum in this study area. A similar usage is also reported in Birecik [15]. Peganum harmala is known as Syrian rue and Harmal. It has varying pharmacological functions such as analgesic, anti-inflammatory, antioxidant, leukemic, hypoglycemic, and antitumor effects [43]. Nevertheless, its notable usage is for protection against evil spirits in Midyat. The same usage is reported in the southeast of Turkey [15, 28, 35]. It is hung on the wall, especially for the protection of babies against evil spirit. This species is additionally reported for its use against heart disease [28], rabies, snake bites, muscle spasms, and food poisoning [30]. Also, Peganum harmala aids in skin and wound healing, as a sedative, to treat inflammations, heart palpitations, nervous system and digestion problems [29, 31]. The seeds of the plant are mixed with honey and used to treat stomach pains [32], and its red fruits used to produce dye in eastern Anatolia [44]. Pistacia terebinthus subsp. palaestina has several different usages in the southeast of Turkey. We found that local people make soup with the plant in Midyat (Fig. 5a), and fresh shoots are eaten to treat stomachache. It is similarly used to make soup in neighboring cities [16], and it heals wounds in Malatya [45], where it is also reported as an ulcer treatment [46]. It is an antiseptic and diuretic, used to reduce fever and high blood pressure and to heal ulcers [31]. The young flowers and fruits are consumed against colds and as diuretic agents and its usage as resin, antimicrobial substances and glue have been reported in eastern Turkey [42].

Fig. 4
figure 4

Usage of Eryngium campestre by local people in Midyat

Fig. 5
figure 5

a. Bitim soup Pistacia terebinthus subsp. palaestina and b. Gundelia tournefortii sold in local markets

In the region, utilizing plants as brooms was a common ethnobotanical usage. Scabiosa argentea is used as a broom (Fig. 6a), and the same usage was reported previously in Şanlıurfa and Birecik [15]. Residents of Midyat use Sideritis libanotica subsp. linearis as a broom and herbal tea. Sideritis libanotica was previously also reported as a broom in eastern Turkey [47]. Additionally, Xeranthemum annum is used as a broom in Midyat (Fig. 6a). The X. annum was similarly used as a broom in Sanliurfa [15]. Sideritis libanotica subsp. linearis is also used in the region as a broom by using the aerial part of the plant.

Fig. 6
figure 6

Some interesting usages: a. Brooms from Midyat. b. Usages of Peganum harmala (nazarlik) and Triticum aestivum (tray)

Some other interesting wood products were found in the region, such as colorful trays and ornaments. As an example, Triticum aestivum is used for the production of traditional carrying trays (Fig. 6b). Similar usage of tray-making was determined in Cizre (Şırnak) [16]. Vitis vinifera and Quercus brantii are commonly used as fuel, and dried branches of these plants are stored on almost all houses in the villages (Fig. 7). People in the region consume many local plants, and sellers use this to their advantage by promoting the locality of the products in Midyat. As an example, stems of Gundelia tournefortii are peeled and eaten fresh, and then sold by local people (Fig. 5b).

Fig. 7
figure 7

Fuel plants Vitis vinifera and Quercus brantii stored on the stone houses in Midyat

In our study area, perhaps the most picturesque ethnobotanical usage is Easter eggs (Fig. 8a-b). They are prepared at Easter by local Christians called Syriacs. First, wet parsley leaves (Petroselinum crispum) were fixed to the egg, and the eggs are boiled slowly with red onion peels (Allium cepa) in a pan. After removing the parsley, the Easter eggs are ready (Fig. 8d). In Turkey, you can see some egg painting in large cities such as Izmir. Local sellers sell these eggs, and people like to buy them because of the attractive shapes.

Fig. 8
figure 8

Traditional usages of Allium cepa in Midyat. a. Government officials celebrate the Easter ceremony by sharing eggs in Midyat [53]. b. Dyed Easter eggs by red onion after decorated with parsley leaves. c. Local people, religious leaders (pastor and imam) as well as government officials come together in an Easter ceremony by sharing eggs in Midyat [53]. Note: A copyright permission was obtained by copyright holder, Dogus Ofset Gazete ve Matbaacilik

The following plants are used as fragrance at the entrance of houses or on top of front doors: Ballota saxatilis, Cyclotrichium leucotrichum, Matricaria aurea, Parietaria judaica, Trigonella monantha. Additionally, fruits of Peganum harmala and Prunus mahaleb are used as ornaments called ‘nazarlık’ against bad spirits, commonly in the southeast of Turkey (Fig. 6b). Euphorbia craspedia is locally used to clean the thick bubble layer on grape molasses. Fruits of Malva neglecta and Rubia tenuifolia subsp. donietti are used as children’s toys in Mardin, and the people of Mardin consume the flowers of Alkanna trichophila var. mardinensis.

Some plants have not previously been reported; these endemic plants are represented in Table 3. Their method of preparation and application are detailed. Four endemic plants were reported (Table 3), Alkanna trichophila var. mardinensis (Boraginaceae), Centaurea kurdica (Asteraceae), Centaurea stapfiana (Asteraceae), and Sideritis libanotica subsp. linearis (Lamiaceae). These plants are used extensively; for example, Centaurea stapfiana is used as fodder for animals. This negatively impacts on the conservation of these plants in the region, and there is an issue trying to protect this species as it can only be found in Midyat. Another species, Centaurea kurdica, is only traditionally used for healing urinary problems and therefore not as endangered as the previous two species. Alkanna trichophila var. mardinensis is locally used by children, who consume the flower latex; it is, however, not extensively used and therefore not in danger. Sideritis libanotica subsp. linearis, whose leaves are used to brew an herbal, and which are also used as brooms, is not a common plant usage, and found in limited locations. The location of Sideritis libanotica makes it challenging to collect because it grows in mountains and in shrubs. Thymbra sintenisii is used as an herbal tea and spice in Icoren villages. It is a very rare plant and can only be found in two places in Turkey, and construction of highways could badly affect populations of this plant. Even though it is not an endemic species, it has a potential for protection in terms of its pharmaceutical features.

Additionally, we observed many similarities between the names of cultured plants from Midyat and those from bordering countries. These findings show a possible relationship between Jordan and Midyat-Batman in terms of migration and languages. We found similar plant names in Midyat and Jordan for seven species [31]: Alcea setosa, Allium cepa, Anchusa strigosa, Pistacia terebinthus subsp. palaestina, Matricaria aurea, Peganum harmala and Teucrium polium. We already know that the common language of the two regions is Arabic. We also compared some of our findings with other studies conducted in bordering countries. For example, Bulgarian–Turk immigrated communities showed more overlapping species among medicinal plants than edible plants in the border regions [48]. In our study, medicinal usages overlapped among different communities. Border regions are important for cross-cultural and cross-border ethnobotany in order to determine changes and variability of medical plant uses and heritage [49]. Even though the region is not very stable right now, an extended study that focuses on cross-border ethnobotany in Turkey, Syria, Iraq, and Iran is needed in future. This is because in the region, only a limited number of ethnobotanical studies have been carried out [15, 16, 50,51,52].

Conclusion

Midyat is a city on the Silk Road, which has welcomed very different cultures and religions for thousands of years. The people of Midyat have lived in peace because of their respect and tolerance to others. Even though people in this region have different backgrounds of religion and culture, they have similar botanical knowledge. Other than red peels of Allium cepa, which are used for painting Easter eggs, they do not have many distinct differences. This type of study will certainly help to uncover, protect, and pass to the next generation the rich cultures of Midyat. The people in Midyat and nearby villages still trust traditional medicine, so in Midyat and its vicinity people continue to use traditional medicines. Our study indicates the importance to document not only medicinal plants, but also edible plants or plants used for fodder, fuel, dyes, and other purposes. We determined the highest UVs for Teucrium polium (0.51) and Matricaria aurea (0.26); further pharmacological study needs to be done for these species. The conservation of this extensive knowledge is crucial, particularly because knowledge is no longer being passed down from older to younger generations. The use of endemic plants is relatively rare, but Centaurea stapfiana, Thymbra sintenisii are used extensively, and their conservation status is compromised by their use as food and fodder plants. Additionally, our findings suggested that Midyat and its vicinity might represent a beginning point for further comparative cross-cultural ethnobotany that can contribute to enhancing the current knowledge of folk medicinal plants and lead to conservation plans for protecting rare plant species.