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Increased DNA Damage is Related to Maternal Blood Glucose Levels in the Offspring of Women With Diabetes and Mild Gestational Hyperglycemia

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Abstract

Objective

This study aimed at correlating maternal blood glucose levels with DNA damage levels in the offspring of women with diabetes or mild gestational hyperglycemia (MGH).

Methodology

Based on oral glucose tolerance test results and glycemic profiles, 56 pregnant women were allocated into 3 groups: nondiabetes, MGH, and diabetes. The offspring of these women (56 infants) were also evaluated. Maternal peripheral blood and umbilical cord blood samples were collected and processed for biochemical and DNA damage analysis by the comet assay.

Results

A positive correlation between maternal blood glucose mean and increased offspring DNA damage levels was observed. Hyperglycemia played a role in offspring DNA damage, but other diabetes-induced complications were also involved.

Conclusion

Increased maternal blood glucose levels can lead to increased offspring DNA damage levels. Therefore, the monitoring, control, and treatment of pregnant women with diabetes and MGH are highly important to ensure a risk-free pregnancy and healthy infants.

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Faculdade de Medicina de Botucatu, Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Univ Estadual Paulista (UNESP), Distrito de Rubião Júnior s/n, CEP. 18618.000, Botucatu, São Paulo, Brazil

    Rafael Bottaro Gelaleti MSc, Débora C. Damasceno PhD, Iracema M. P. Calderon PhD & Marilza V. C. Rudge PhD

  2. Post-graduate Program in Endocrinology, Laboratory for Cellular and Molecular Endocrinology (LIM-25), School of Medicine, University of São Paulo (USP), São Paulo, São Paulo, Brazil

    Daniele P. Santos MSc

Authors
  1. Rafael Bottaro Gelaleti MSc
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  2. Débora C. Damasceno PhD
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  3. Daniele P. Santos MSc
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  4. Iracema M. P. Calderon PhD
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  5. Marilza V. C. Rudge PhD
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Correspondence to Rafael Bottaro Gelaleti MSc.

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Gelaleti, R.B., Damasceno, D.C., Santos, D.P. et al. Increased DNA Damage is Related to Maternal Blood Glucose Levels in the Offspring of Women With Diabetes and Mild Gestational Hyperglycemia. Reprod. Sci. 23, 318–323 (2016). https://doi.org/10.1177/1933719115602766

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  • DOI: https://doi.org/10.1177/1933719115602766

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