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Peptides in Seminal Fluid and Their Role in Infertility: A Potential Role for Opiorphin Inhibition of Neutral Endopeptidase Activity as a Clinically Relevant Modulator of Sperm Motility: A Review

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Abstract

Infertility is a devastating medical condition that adversely affects emotional health and well-being of couples who desire pregnancy and parenthood. The overall demographic data suggest that the indication for more than one-third of assisted reproductive technology cycles performed in the United States includes male factor infertility. There is increasing recognition of the role that peptides present in seminal plasma have in determining sperm motility. Several recent studies suggest that peptidases, such as neutral endopeptidase (NEP) and aminopeptidase N (APN), impose significant adverse effects on sperm motility. Interestingly, several recent studies demonstrate that there is an endogenous NEP/APN inhibitor peptide called opiorphin in human seminal plasma. Our pilot studies suggest opiorphin promotes sperm motility and may positively influence sperm motility parameters in some cases of males infertility characterized by asthenozoospermia.

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Authors and Affiliations

  1. Department of Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Block 621, 10461, Bronx, NY, USA

    Jayme S. Bosler MD & Genevieve S. Neal-Perry MD, PhD

  2. Montefiore Medical Center Institute for Reproductive Medicine and Health, Hartsdale, NY, USA

    Jayme S. Bosler MD & Genevieve S. Neal-Perry MD, PhD

  3. Department of Urology and Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, USA

    Kelvin P. Davies PhD

  4. Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA

    Genevieve S. Neal-Perry MD, PhD

Authors
  1. Jayme S. Bosler MD
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  2. Kelvin P. Davies PhD
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  3. Genevieve S. Neal-Perry MD, PhD
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Correspondence to Jayme S. Bosler MD.

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Bosler, J.S., Davies, K.P. & Neal-Perry, G.S. Peptides in Seminal Fluid and Their Role in Infertility: A Potential Role for Opiorphin Inhibition of Neutral Endopeptidase Activity as a Clinically Relevant Modulator of Sperm Motility: A Review. Reprod. Sci. 21, 1334–1340 (2014). https://doi.org/10.1177/1933719114536473

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