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Cytogenetic status in coal miners with occupational pulmonary diseases and influence of the polymorphisms of the XpD and XpG genes

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Russian Journal of Genetics: Applied Research

Abstract

The genotoxic influence of anthracosilicosis (AC) and chronic dust bronchitis (CDB) on coal miners has been studied. Venous blood samples has been extracted from 90 coal miners with various occupational pulmonary diseases and 26 healthy coal miners (control group 2). Blood samples obtained from 124 non-exposed men were used as control group 1. We have found a significant increase in the frequency of the chromatid- and chromosome-type aberrations in coal miners and an increase of the chromosomal interchange in miners with occupational pulmonary diseases. The effects of the XpD and XpG genes on the level of chromosome aberrations, as well as the effect of the XpG gene on occupational pulmonary diseases, were discovered.

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Authors and Affiliations

  1. Kemerovo State University, ul. Krasnaya 6, Kemerovo, 650000, Russia

    V. P. Volobaev, M. Y. Sinitsky & Y. E. Kulemin

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  1. V. P. Volobaev
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  2. M. Y. Sinitsky
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  3. Y. E. Kulemin
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Correspondence to V. P. Volobaev.

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Original Russian Text © V.P. Volobaev, M.Y. Sinitsky, Y.E. Kulemin, 2015, published in Ecologicheskaya Genetika, 2015, Vol. 13, No. 4, pp. 12–15.

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Volobaev, V.P., Sinitsky, M.Y. & Kulemin, Y.E. Cytogenetic status in coal miners with occupational pulmonary diseases and influence of the polymorphisms of the XpD and XpG genes. Russ J Genet Appl Res 7, 214–216 (2017). https://doi.org/10.1134/S2079059717020162

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  • DOI: https://doi.org/10.1134/S2079059717020162

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