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Interrelation of Changes in the Left Ventricular Myocardium and Evidence of Clinical and Laboratory Indicators in Chronic Kidney Disease of Elderly

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Abstract

The incidence of cardiovascular and kidney disease with age is growing steadily worldwide. The factors for cardiovascular and kidney diseases are similar at elderly ages. Left ventricular hypertrophy (LVH) in chronic kidney disease (CKD) at an elderly age is not well understood. The goal of this study was to examine changes in a structural state of the left ventricular myocardium depending on the severity of clinical and laboratory manifestations of CKD in elderly patients. Clinical, laboratory, and instrumental examination of 62 patients at ages of 60 to 74 years (the young old) was carried out; the average age was 63.7 ± 3.66 years. The study involved the analysis of parameters of red blood, lipid spectrum, creatinine, daily proteinuria, C-reactive protein, and blood electrolytes. Glomerular filtration rate (GFR) was assessed using the CKD-EPI formula. The eccentric type was found to be the predominant variant of LVH at the early stages of CKD (S1, S2, and S3) at elderly ages. In the presence of renal failure (S4 and S5 of CKD), changes in the structure of the myocardium are characterized by a predominantly concentric type of left ventricular remodeling in the elderly. The factors associated with the development of left ventricular remodeling in elderly patients with CKD included age, arterial hypertension, anemia, dyslipidemia, and proteinuria, as well as an appreciable decline in the level of GFR.

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Authors and Affiliations

  1. Akhunbaev Kyrgyz State Medical Academy, 720020, Bishkek, Kyrgyz Republic

    I. T. Murkamilov

  2. Kyrgyz-Russian Slavic University, 720000, Bishkek, Kyrgyz Republic

    I. T. Murkamilov, I. S. Sabirov & Zh. A. Murkamilova

  3. Sechenov First State Medical University, 119991, Moscow, Russia

    V. V. Fomin

  4. Osh State University, 723500, Osh, Kyrgyz Republic

    F. A. Yusupov

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  1. I. T. Murkamilov
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  4. Zh. A. Murkamilova
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Correspondence to I. T. Murkamilov.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study. Informed consent was obtained from all individual participants involved in the study.

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Translated by E. Kuznetsova

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Murkamilov, I.T., Sabirov, I.S., Fomin, V.V. et al. Interrelation of Changes in the Left Ventricular Myocardium and Evidence of Clinical and Laboratory Indicators in Chronic Kidney Disease of Elderly. Adv Gerontol 12, 72–78 (2022). https://doi.org/10.1134/S207905702201009X

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