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Role of Myeloperoxidase, Paraoxonase, and Nitric Oxide System in the Blood and Pericardial Fluid of Patients with Ischemic Heart Disease after Direct Myocardial Revascularization

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Abstract

To study the role of paraoxonase, myeloperoxidase, arginase, asymmetric dimethylarginine, and nitric oxide in the mechanisms of the pathogenesis of postpericardiotomy syndrome (PPCS), 76 patients with ischemic heart disease (IHD) who underwent coronary artery bypass grafting were examined. Patients were divided into two groups: Group 1, IHD patients who were not diagnosed with PPCS as a result of clinical studies, and Group 2, IHD patients who were diagnosed with PPCS. The results indicate that the postoperative period after coronary artery bypass grafting is associated with the inhibition of paraoxonase, the activation of myeloperoxidase, enhanced arginase activity, increased nitrite/nitrate and asymmetric dimethylarginine levels; it may also be accompanied by the development of endothelial dysfunction and increased systemic inflammatory response. In the present work, inverse correlations were found between the paraoxonase aryl esterase activity and myeloperoxidase activity in plasma, as well as the paraoxonase aryl esterase activity in blood plasma and arginase activity in erythrocytes in patients of both groups. Tests to predict the development of postpericardiotomy syndrome were developed based on the ratio of activity of the studied enzymes.

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ACKNOWLEDGMENTS

The study was performed on the equipment of the High Technologies Center for Collective Use at Southern Federal University.

Funding

The study was carried out in the framework of the basic part of the State Assignment of the Ministry of Education and Science of the Russian Federation (projects no. 1878 and no. 6.6762.2017/BCh).

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Authors and Affiliations

  1. Southern Federal University, 344006, Rostov-on-Don, Russia

    V. V. Vnukov, D. Yu. Gvaldin, N. P. Milyutina, A. A. Ananyan & A. A. Plotnikov

  2. Rostov State Medical University, 344022, Rostov-on-Don, Russia

    R. V. Sidorov, D. Yu. Pospelov, I. F. Shlyk & N. S. Doltmurzieva

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  1. V. V. Vnukov
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  2. R. V. Sidorov
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  3. D. Yu. Gvaldin
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  4. N. P. Milyutina
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  5. A. A. Ananyan
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  6. D. Yu. Pospelov
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  7. A. A. Plotnikov
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  9. N. S. Doltmurzieva
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Correspondence to V. V. Vnukov.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by G. Levit

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Vnukov, V.V., Sidorov, R.V., Gvaldin, D.Y. et al. Role of Myeloperoxidase, Paraoxonase, and Nitric Oxide System in the Blood and Pericardial Fluid of Patients with Ischemic Heart Disease after Direct Myocardial Revascularization. Adv Gerontol 9, 426–433 (2019). https://doi.org/10.1134/S2079057019040167

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