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Age-dependent changes in the neurochemical properties of sensory neurons

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Abstract

Sensory neurons represent a heterogenous population of neurons with different morphological, receptor, and immunohistochemical characteristics. The majority of large neurons with myelinated Aδ-fibers contain the neurofilament protein 200 kDa (NF200); some small afferent neurons can bind to isolectin B4 (IB4). Sensory neurons also may contain different types of tyrosine kinases (TrkA, B, and C) and neurotrans-mitters. Neuropeptides are generally located in small and medium-sized neurons. The proportion of neurons containing TrkA decreases and the percentage of NF200-, IB4-, substance P- and CGRP-positive neurons increases during early development. The growth and development of different types of sensory neurons is controlled by neurotrophins.

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Authors and Affiliations

  1. Yaroslavl State Medical Academy, ul. Revolutsionnaya 5, Yaroslavl, 150000, Russia

    P. M. Masliukov, M. B. Korzina & V. V. Porseva

  2. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St. Petersburg, 199034, Russia

    E. Yu. Bystrova & A. D. Nozdrachev

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  1. P. M. Masliukov
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  2. M. B. Korzina
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  3. V. V. Porseva
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  4. E. Yu. Bystrova
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  5. A. D. Nozdrachev
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Correspondence to P. M. Masliukov.

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Original Russian Text © P.M. Masliukov, M.B. Korzina, V.V. Porseva, E.Yu. Bystrova, A.D. Nozdrachev, 2013, published in Uspekhi Gerontologii, 2013, Vol. 26, No. 4, pp. 620–630.

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Masliukov, P.M., Korzina, M.B., Porseva, V.V. et al. Age-dependent changes in the neurochemical properties of sensory neurons. Adv Gerontol 4, 176–186 (2014). https://doi.org/10.1134/S2079057014030047

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