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Neurochemical Characteristics of Sensory Neurons During Ontogeny

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Sensory neurons constitute a heterogeneous population of neurons with different morphological, receptor, and immunohistochemical characteristics. Most large neurons with myelinated fibers of the Aδ group contain 200-kDal neurofilament protein (NF200), while some small afferent intervertebral ganglion neurons can bind isolectin B4 (IB4). Sensory neurons can contain different types of tyrosine kinase (A, B, and C) and have different neurotransmitter compositions. Neuropeptides are found mainly in neurons of small and intermediate size. The proportion of neurons containing tyrosine kinase A decreases and the proportions of neurons positive for NF200, IB4, substance P, and CGRP increase during early postnatal ontogeny. The growth and development of sensory neurons, especially during the embryonic period, occurs under the influence of neurotrophins.

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Authors and Affiliations

  1. Yaroslavl State Medical Academy, Ministry of Health of the Russian Federation, Yaroslavl, Russia

    P. M. Maslyukov, V. V. Porseva & M. B. Korzina

  2. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. D. Nozdrachev

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  1. P. M. Maslyukov
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  2. V. V. Porseva
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  3. M. B. Korzina
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  4. A. D. Nozdrachev
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Correspondence to P. M. Maslyukov.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 99, No. 7, pp. 777–792, July, 2013.

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Maslyukov, P.M., Porseva, V.V., Korzina, M.B. et al. Neurochemical Characteristics of Sensory Neurons During Ontogeny. Neurosci Behav Physi 45, 440–448 (2015). https://doi.org/10.1007/s11055-015-0094-8

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