Skip to main content
SpringerLink
Log in

Study of Structural and Morphological Changes during Accelerated Oxidative Degradation of Mixtures of Polyoxybutyrate with Polycaprolactone

  • NEW METHODS OF TREATMENT AND PRODUCTION OF MATERIALS WITH REQUIRED PROPERTIES
  • Published:
Inorganic Materials: Applied Research Aims and scope

Abstract

Structural and morphological changes in the film samples of poly(oxybutyrate-co-oxyvalerate) (P(OB-OV)) and poly-ε-caprolactone (PCL) during accelerated oxidative degradation in the Fenton reagent are studied by IR spectroscopy, DSC, and scanning electron microscopy. It is shown that phase separation of the P(OB-OV) and PCL components is observed in the initial mixture. The melting of different phases of P(OB-OV) is observed at 147 and 157°C, and PCL melts at 61°C. The degrees of crystallinity of P(OB-OV) and PCL in the mixture are 67 and 50%, respectively. It is found that the degradation of P(OB-OV) predominates during the incubation of the samples of the composite in the Fenton solution for 2 to 12 weeks. It is possible to substantially change the rate of oxidative degradation and the molecular weight and degree of crystallinity of a P(OB-OV):PCL polymer composite material by varying the ratio of the components.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.
Fig. 8.
Fig. 9.

Similar content being viewed by others

REFERENCES

  1. Shick, T.M., Abdul Kadir, A.Z., Ngadiman, N.H.A., and Ma’aram, A., A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering, J. Bioact. Compat. Polym., 2019, vol. 34, no. 6, pp. 415–435.

    Article  CAS  Google Scholar 

  2. Sevast’yanov, V.I. and Kirpichnikov, M.P., Biosovmestimye materialy (Biocompatible Materials), Moscow: Nauka, 2011.

  3. Pina, S., Ribeiro, V.P., Marques, C.F., Maia, F.R., Silva, T.H., Reis, R.L., and Oliveira, J.M., Scaffolding strategies for tissue engineering and regenerative medicine applications, Materials, 2019, vol. 12, pp. 1824–1832.

    Article  CAS  Google Scholar 

  4. Jafari, M., Paknejad, Z., Rezai, R.M., Motamedian, S.R., Eghbal, M.J., Nadjmi, N., and Khojasteh, A., Polymeric scaffolds in tissue engineering: A literature review, J. Biomed. Mater. Res., Part B, 2017, vol. 105, pp. 431–459.

    Article  CAS  Google Scholar 

  5. Shtilman, N.I., Biodegradation of polymers, Zh. Sib. Fed. Univ., Ser. Biol., 2015, vol. 8, no. 2, pp. 113–130.

    Google Scholar 

  6. Volova, T.G., Sevast’yanov, V.I., and Shishatskaya, E.I., Polioksialkanoaty—biorazrushaemye polimery dlya meditsiny (Polyhydroxyalkanoates—Biodegradable Polymers for Medicine), Krasnoyarsk: Platina, 2006.

  7. Abedalwafa, M., Wang, F., Wang, L., and Li, C., Biodegradable poly-epsilon-caprolactone (PCL) for tissue engineering applications: A review, Rev. Adv. Mater. Sci., 2013, vol. 34, pp. 123–140.

    CAS  Google Scholar 

  8. Buchanan, F., Degradation Rate of Bioresorbable Materials: Prediction and Evaluation, Cambridge: Woodhead, 2008, part 2.

  9. Thottappillil, N. and Nair, P.D., Scaffolds in vascular regeneration: Current status, Vasc. Health Risk Manage., 2015, vol. 11, pp. 79–91.

    Google Scholar 

  10. Siddiqui, N., Asawa, S., Birru, B., Baadhe, R., and Rao, S., PCL-based composite scaffold matrices for tissue engineering applications, Mol. Biotechnol., 2018, vol. 60, no. 7, pp. 506–532.

    Article  CAS  Google Scholar 

  11. Blümm, E. and Owen, A., Miscibility, crystallization and melting of poly(3-hydroxybutyrate)/poly(l–lactide) blends, J. Polym., 1995, vol. 36, pp. 4077–4081.

    Article  Google Scholar 

  12. Furukawa, T., Sato, H., Murakami, R., Zhang, J., Duan, Y.-X., Noda, I., Ochiai, S., and Ozaki, Y., Structure, dispersibility, and crystallinity of poly(hydroxybutyrate)/poly(L-lactic acid) blends studied by FT-IR microspectroscopy and differential scanning calorimetry, Macromolecules, 2005, vol. 38, pp. 6445–6454.

    Article  CAS  Google Scholar 

  13. Zhang, L., Xiong, C., and Deng, X., Miscibility, crystallization and morphology of poly(β-hydroxybutyrate)/poly(d,l-lactide) blends, Polymer, 1996, vol. 37, pp. 235–241.

    Article  CAS  Google Scholar 

  14. Gassner, F. and Owen, A.J., Physical properties of poly(β-hydroxybutyrate)-poly(varepsilon-caprolactone) blends, Polymer, 1994, vol. 35, pp. 2233–2236.

    Article  CAS  Google Scholar 

  15. Avella, M. and Martuscelli, E., Poly-d-(–)(3-hydroxybutyrate)/poly(ethylene oxide) blends: Phase diagram, thermal and crystallization behavior, Polymer, 1988, vol. 29, pp. 1731–1737.

    Article  CAS  Google Scholar 

  16. Lotti, N., Pizzoli, M., Ceccorulli, G., and Scando-la, M., Binary blends of microbial poly(3-hydroxybutyrate) with polymethacrylates, Polymer, 1993, vol. 34, pp. 4935–4040.

    Article  CAS  Google Scholar 

  17. Kaito, A., Unique orientation textures formed in miscible blends of poly(vinylidene fluoride) and poly[(R)-3-hydroxybutyrate], Polymer, 2006, vol. 47, pp. 3548–3556.

    Article  CAS  Google Scholar 

  18. Scandola, M., Ceccorulli, G., and Pizzoli, M., Miscibility of bacterial poly(3-hydroxybutyrate) with cellulose esters, Macromolecules, 1992, vol. 25, pp. 6441–6446.

    Article  CAS  Google Scholar 

  19. Godbole, S., Gote, S., Latkar, M., and Chakrabar-ti, T., Preparation and characterization of biodegradable poly-3-hydroxybutyrate-starch blend films, Bioresour. Technol., 2003, vol. 86, pp. 33–37.

    Article  CAS  Google Scholar 

  20. Sato, H., Mori, K., Murakami, R., Ando, Y., Takahashi, I., Zhang, J., Terauchi, H., Hirose, F., Senda, K., Tashiro, K., Noda, I., and Ozaki, Y., Crystal and lamella structure and C–H center dot center dot center dot O=C hydrogen bonding of poly(3-hydroxyalkanoate) studied by X-ray diffraction and infrared spectroscopy, Macromolecules, 2006, vol. 39, pp. 1525–1531.

    Article  CAS  Google Scholar 

  21. Eastmond, G.C., Biomedical applications of polymer blends, Adv. Polym. Sci., 1999, vol. 149, pp. 59–223.

    Article  CAS  Google Scholar 

  22. GOST (State Standard) R ISO 10993-13-2016: Medical Devices. Biological Evaluation of Medical Devices. Part 13. Identification and Quantification of Degradation Products from Polymeric Medical Devices, 2017.

  23. Barham, P.J., Keller, A., Otun, E.L., and Holmes, P.A., Crystallization and morphology of a bacterial thermoplastic: Poly-3-hydroxybutyrate, J. Mater. Sci., 1984, vol. 19, no. 9, pp. 2781–2794.

    Article  CAS  Google Scholar 

Download references

Funding

This work was partially supported by the Ministry of Science and Higher Education within the execution of the works in line with the State Task to the Branch of the Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, state registration number AAAA-A18-118112290069-6, in the part of measuring the degree of crystallinity and thermophysical characteristics of the polymer.

Author information

Authors and Affiliations

  1. Shumakov National Medical Research Center of Transplantology and Artificial Organs, 123192, Moscow, Russia

    V. N. Vasilets, E. A. Nemets & V. I. Sevastianov

  2. ANO Institute of Biomedical Research and Technologies, 123557, Moscow, Russia

    A. P. Pankina, V. Yu. Belov & V. I. Sevastianov

  3. Branch of the Semenov Federal Research Center of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    V. N. Vasilets

Authors
  1. V. N. Vasilets
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. P. Pankina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. A. Nemets
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. Yu. Belov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. I. Sevastianov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to V. N. Vasilets, A. P. Pankina, E. A. Nemets, V. Yu. Belov or V. I. Sevastianov.

Ethics declarations

The authors declare that they have no conflicts of interest.

Additional information

Translated by E. Boltukhina

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vasilets, V.N., Pankina, A.P., Nemets, E.A. et al. Study of Structural and Morphological Changes during Accelerated Oxidative Degradation of Mixtures of Polyoxybutyrate with Polycaprolactone. Inorg. Mater. Appl. Res. 13, 872–878 (2022). https://doi.org/10.1134/S2075113322030364

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S2075113322030364

Keywords:

Search

Navigation