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Effect of Highly Porous Bioceramics Based on ZrO2–Y2O3–CeO2 System on the Biological Tissues of Experimental Animals

  • MATERIALS FOR HUMAN LIFE SUPPORT AND ENVIRONMENTAL PROTECTION
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Inorganic Materials: Applied Research Aims and scope

Abstract

By reverse codeposition of hydroxides, highly dispersed powder (the average size of 8–10 nm) of the composition (ZrO2)0.92(Y2О3)0.03(СеО2)0.05 is synthesized; on the basis of it, with use of a comprehensive a blowing agent and mechanical activation, a highly porous ceramic (average grain size of 60–65 nm) is obtained. The synthesized ceramic material—an implant with an open porosity of 55% and a pore size of 40–800 nm—was placed in the body of laboratory animals. The reaction of biological tissues of experimental animals to the introduction of plates made of composite highly porous materials based on t-ZrO2 15 months after their implantation was studied. It is revealed that enhanced revascularization is registered in capsules, and perfusion of tissues is registered in the intact zone of ceramic introduction. The possibility of germination of vessels in soft tissues into the available pore space of the ceramic is shown. The results obtained in vivo suggest that porous bioceramics based on t-ZrO2 can be used in the production of endoprostheses and implants in such areas of medicine as orthopedics and traumatology.

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Funding

This work was carried out within the framework of the State Assignment of the Institute of Silicate Chemistry of the Russian Academy of Sciences (state registration number (TsITiS): AAAA-A19-119022290091-8; unique number (ISGZ): no. 0097-2019-0017).

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Authors and Affiliations

  1. Grebenschikov Institute of Silicate Chemistry, Russian Academy of Sciences, 199034, St. Petersburg, Russia

    M. V. Kalinina, N. Yu. Kovalko & O. A. Shilova

  2. Russian Scientific Center of Radiology and Surgical Technologies, 197758, St. Petersburg, Russia

    D. N. Suslov

  3. Pavlov First St. Petersburg State Medical University, 197022, St. Petersburg, Russia

    Yu. S. Andozhskaia & O. V. Galibin

Authors
  1. M. V. Kalinina
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  2. N. Yu. Kovalko
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  3. D. N. Suslov
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  4. Yu. S. Andozhskaia
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  5. O. V. Galibin
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  6. O. A. Shilova
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Correspondence to M. V. Kalinina.

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Conflict of interest. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and institutional guidelines for the care and use of animals have been followed.

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Translated by P. Kuchina

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Kalinina, M.V., Kovalko, N.Y., Suslov, D.N. et al. Effect of Highly Porous Bioceramics Based on ZrO2–Y2O3–CeO2 System on the Biological Tissues of Experimental Animals. Inorg. Mater. Appl. Res. 12, 370–376 (2021). https://doi.org/10.1134/S2075113321020209

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  • DOI: https://doi.org/10.1134/S2075113321020209

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