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Potential and Capabilities of Porous Silicon as a Material for Intravascular Drug-Eluting Stents: Brief Summary

  • PHYSICOCHEMICAL PRINCIPLES OF CREATING MATERIALS AND TECHNOLOGIES
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Inorganic Materials: Applied Research Aims and scope

Abstract

In search for a drug-containing material when creating polymer-free drug-eluting stents, an analysis of the available literature is carried out. It is shown that one of the promising materials for this purpose is mesoporous silicon (the cross-sectional pore diameter is 2–50 nm), which has high biocompatibility and biodegradability. The main requirements for the porous silicon coating as a drug carrier of metal intravascular stents are formulated. The results of experimental studies are presented, including those performed by the authors, showing the possibility of continuous silicon coating application up to 0.6 μm thick on the stents by magnetron sputtering or plasma-immersion ion implantation and deposition (PIII@D). These methods provide high coating adhesion to the stent material and allow coating both on the external and internal stent surfaces.

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Funding

The work was carried out as part of the Program of Fundamental Scientific Research of the State Academies of Sciences of the Russian Federation for 2013–2020, project III.23.2.2.

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  1. Institute of Strength Physics and Materials Science, Siberian Branch, Russian Academy of Sciences, 634055, Tomsk, Russia

    O. A. Kashin, K. V. Krukovskii & A. I. Lotkov

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  1. O. A. Kashin
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Kashin, O.A., Krukovskii, K.V. & Lotkov, A.I. Potential and Capabilities of Porous Silicon as a Material for Intravascular Drug-Eluting Stents: Brief Summary. Inorg. Mater. Appl. Res. 11, 287–296 (2020). https://doi.org/10.1134/S2075113320020161

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