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Magnetic Isotope Effect on the Repair of Radiation-Induced DNA Damage

  • CHEMICAL PHYSICS OF BIOLOGICAL PROCESSES
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Russian Journal of Physical Chemistry B Aims and scope Submit manuscript

Abstract

The rate of DNA repair in human blood lymphocytes exposed to γ-radiation was shown to depend on the nuclear magnetic moment of magnesium ions. The decrease of DNA double-strand breaks occurs as a first-order reaction with the rate constants 1.1 × 10–3 s–1 and 1.6 × 10–3 s–1 for 25Mg2+ and 24Mg2+ ions respectively. Their ratio certifies magnetic isotope effect on the DNA repair; the latter occurs by 1.5 times slower with nuclear-magnetic 25Mg2+ ions than with nuclear nonmagnetic 24Mg2+ ions. The discovery of this effect is an irrefutable indicator that the DNA repair is spin-dependent and magneto-sensitive process, and its chemistry includes electron transfer and generation of radicals and radical pairs.

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Funding

The work was supported by the FRCCP RAS state task (АААА-А18-118020690203-8).

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Authors and Affiliations

  1. Semenov Federal Scientific Center for Chemical Physics Russian Academy of Sciences, 119991, Moscow, Russia

    E. Yu. Arkhangelskaya, N. Yu. Vorobyeva, A. N. Osipov & A. L. Buchachenko

  2. Moscow Institute of Physics and Technology, 141701, Dolgoprudny, Moscow oblast, Russia

    S. V. Leonov & A. N. Osipov

  3. Institute of Cell Biophysics Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    S. V. Leonov

  4. Institute of Problems of Chemical Physics Russian Academy of Sciences, 142432, Chernogolovka, Russia

    A. L. Buchachenko

  5. Scientific Center of the Russian Academy of Sciences, 142432, Chernogolovka, Russia

    A. L. Buchachenko

  6. Moscow State University, 119991, Moscow, Russia

    A. L. Buchachenko

Authors
  1. E. Yu. Arkhangelskaya
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  2. N. Yu. Vorobyeva
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  3. S. V. Leonov
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  4. A. N. Osipov
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  5. A. L. Buchachenko
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Correspondence to A. N. Osipov.

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Arkhangelskaya, E.Y., Vorobyeva, N.Y., Leonov, S.V. et al. Magnetic Isotope Effect on the Repair of Radiation-Induced DNA Damage. Russ. J. Phys. Chem. B 14, 314–317 (2020). https://doi.org/10.1134/S1990793120020177

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  • DOI: https://doi.org/10.1134/S1990793120020177

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